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Semagacestat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842542

Background: A potent gamma-secretase inhibitor (IC?? = 10.9 nM, 12.1 nM and 12.0 nM for Abeta42, Abeta40 and Abeta38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid-beta in vitro and in vivo. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Semagacestat, Biochemical
Full Product Name
Semagacestat
Product Synonym Names
(S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide ; LY450139
Form/Format
Appearance: White solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
361.44
CAS Number
425386-60-3
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
9843750
Solubility/Reconstitution Instructions
DMSO (>60 mg/ml) or EtOH (>40 mg/ml)
SMILES
CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O
InChi
InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
InChi Key
PKXWXXPNHIWQHW-RCBQFDQVSA-N
Handling
Protect from light and air

Product Categories/Family for Semagacestat biochemical

Enzyme Inhibitors; Secretase Inhibitors and Biochemicals; Enzyme Inhibitors; Secretase Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of Semagacestat biochemical

Semagacestat Biochemical – Cat# MBS842542

Other Notes

Small volumes of Semagacestat biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Semagacestat purchase

MBS842542 is a biochemical targeting Semagacestat.
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