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JAK Inhibitor, Pyridone 6

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842591

Background: Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC?? values of 15, 1, and 5 nM, respectively. Displays signi?cantly weaker affinities (IC??s = 130 nM - > 10 muM) for… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
JAK Inhibitor, Pyridone 6, Biochemical
Full Product Name
JAK Inhibitor, Pyridone 6
Product Synonym Names
2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one; Pyridone 6; CMP 6
Form/Format
Appearance: Off-white solid
Purity/Purification
>=97% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
309.3
CAS Number
457081-03-7
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD17019334
PubChem CID
5494425
Solubility/Reconstitution Instructions
DMSO (5 mg/ml)
SMILES
CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
InChi
InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChi Key
VNDWQCSOSCCWIP-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for JAK Inhibitor, Pyridone 6 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Signaling Pathways; JAK/Stat Signaling; JAK Inhibitors and Diabetes; Ob

Structure of JAK Inhibitor, Pyridone 6 biochemical

JAK Inhibitor, Pyridone 6 Biochemical – Cat# MBS842591

Other Notes

Small volumes of JAK Inhibitor, Pyridone 6 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAK Inhibitor, Pyridone 6 purchase

MBS842591 is a biochemical targeting JAK Inhibitor, Pyridone 6.
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