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HPI-1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842625

Background: HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HPI-1, Biochemical
Full Product Name
HPI-1
Product Gene Name
HPI-1 biochemical
Product Synonym Names
2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Form/Format
Appearance: Yellow solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
463.52
CAS Number
599150-20-6
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD17215941
PubChem CID
71311904
Solubility/Reconstitution Instructions
DMSO (~25 mg/ml) or EtOH (~25 mg/ml)
SMILES
CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O
InChi
InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2
InChi Key
BOASXIAGFOONSK-UHFFFAOYSA-N
Handling
Protect from light and air

Product Categories/Family for HPI-1 biochemical

Enzyme Inhibitors; Hedgehog (Hh) Signaling Pathway Antagonists and Biochemicals; Enzyme Inhibitors; Hedgehog (Hh) Signaling Pathway Antagonists and Signaling Pathways; Hedgehog (Hh) Signaling; Hedgehog (Hh) Signaling Pathway Antagonists and Biochemicals;

Structure of HPI-1 biochemical

HPI-1 Biochemical – Cat# MBS842625

Other Notes

Small volumes of HPI-1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HPI-1 purchase

MBS842625 is a biochemical targeting HPI-1.
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