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BTK Inhibitor, CNX-774

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842676

Background: CNX-774 is a potent, irreversible BTK inhibitor (IC?? < 1 nM). CNX-774 is highly selective for BTK, and forms a ligand-directed covalent bond with the Cys-481 residue within the ATP binding site of the enzyme. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
BTK Inhibitor, CNX-774, Biochemical
Full Product Name
BTK Inhibitor, CNX-774
Product Synonym Names
4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
Form/Format
Appearance: Crystalline solid
Purity/Purification
>98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
499.5
CAS Number
1202759-32-7
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
59174579
Solubility/Reconstitution Instructions
DMSO
SMILES
 CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F
InChi
 InChI=1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28,36)(H,31,35)(H2,30,32,33,34)
InChi Key
VVLHQJDAUIPZFH-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for BTK Inhibitor, CNX-774 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of BTK Inhibitor, CNX-774 biochemical

BTK Inhibitor, CNX-774 Biochemical – Cat# MBS842676

Other Notes

Small volumes of BTK Inhibitor, CNX-774 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BTK Inhibitor, CNX-774 purchase

MBS842676 is a biochemical targeting BTK Inhibitor, CNX-774.
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