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EPZ004777

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842677

Background: A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
EPZ004777, Biochemical
Full Product Name
EPZ004777
Product Gene Name
EPZ004777 biochemical
Product Synonym Names
1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
Form/Format
Appearance: Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
539.67
CAS Number
1338466-77-5
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
70702060
Solubility/Reconstitution Instructions
DMSO
SMILES
CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
InChi
InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
InChi Key
WXRGFPHDRFQODR-QQNJPBSNSA-N
Handling
Protect from light and air

Product Categories/Family for EPZ004777 biochemical

Enzyme Inhibitors; Methyltransferase Inhibitors and Biochemicals; Enzyme Inhibitors; Methyltransferase Inhibitors and Epigenetics; Writer Enzymes; Protein Lysine Methyltransferases (PKMTs); PKMT Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of EPZ004777 biochemical

EPZ004777 Biochemical – Cat# MBS842677

Other Notes

Small volumes of EPZ004777 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPZ004777 purchase

MBS842677 is a biochemical targeting EPZ004777.
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