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KRN-633

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842756

Background: KRN-633 is a cell-permeable, reversible, and ATP-competitive inhibitor of VEGFR kinase activity (IC?? values of 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). At higher concentrations KRN 633 inhibits PDGFR-alpha and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
KRN-633, Biochemical
Full Product Name
KRN-633
Product Gene Name
KRN-633 biochemical
Product Synonym Names
N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-urea
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
416.86
CAS Number
286370-15-8
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
9549295
Solubility/Reconstitution Instructions
DMSO (>8 mg/ml)
SMILES
CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
InChi
nChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChi Key
VPBYZLCHOKSGRX-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for KRN-633 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzym

Structure of KRN-633 biochemical

KRN-633 Biochemical – Cat# MBS842756

Other Notes

Small volumes of KRN-633 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRN-633 purchase

MBS842756 is a biochemical targeting KRN-633.
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