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SB-525334

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842764

Background: SB-525334 is a potent and selective inhibitor of transforming growth factor-beta receptor I (ALK5, TGF-betaRI) (IC?? = 14.3 nM); displays 4-fold less potency against ALK4 (IC?? = 58.5 nM) and inactive as an inhibitor of ALK2, ALK3, and ALK6… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SB-525334, Biochemical
Full Product Name
SB-525334
Product Gene Name
SB-525334 biochemical
Product Synonym Names
6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Form/Format
Appearance: Orange solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
343.42
CAS Number
356559-20-1
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD11045307
PubChem CID
9967941
Solubility/Reconstitution Instructions
DMSO (>30 mg/ml)
SMILES
CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
InChi
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChi Key
DKPQHFZUICCZHF-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for SB-525334 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzym

Structure of SB-525334 biochemical

SB-525334 Biochemical – Cat# MBS842764

Other Notes

Small volumes of SB-525334 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SB-525334 purchase

MBS842764 is a biochemical targeting SB-525334.
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