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Necrostatin-1 (PCSK1)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842768

Background: Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC?? = 180 nM). More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Necrostatin-1 (Pcsk1), Biochemical
Full Product Name
Necrostatin-1
Product Gene Name
Product Synonym Names
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1
Form/Format
Appearance: Yellow solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
259.33
CAS Number
4311-88-0
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD00056916
PubChem CID
2828334
Solubility/Reconstitution Instructions
DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)
SMILES
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChi
InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Handling
Protect from air and light

Structure of Pcsk1 biochemical

PCSK1 Necrostatin-1 Biochemical – Cat# MBS842768

Other Notes

Small volumes of Pcsk1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pcsk1 purchase

MBS842768 is a biochemical targeting Pcsk1. Also known as Necrostatin-1.

Additional Details

NCBI/Uniprot data below describe general gene information for Pcsk1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neuroendocrine convertase 1
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 1
NCBI Official Symbol
Pcsk1
NCBI Official Synonym Symbols
PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1
UniProt Protein Name
Neuroendocrine convertase 1
UniProt Synonym Protein Names
Furin homolog; PC3; Prohormone convertase 1; Propeptide-processing protease; Proprotein convertase 1; PC1
UniProt Gene Name
Pcsk1
UniProt Synonym Gene Names
Att-1; Nec-1; Nec1; NEC 1; PC1
UniProt Entry Name
NEC1_MOUSE
NCBI Protein Information
neuroendocrine convertase 1

UniProt Comments for Pcsk1

PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily.

Protein type: Protease; EC 3.4.21.93

Cellular Component: Golgi apparatus; extracellular space; cytoplasmic vesicle

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity

Biological Process: peptide hormone processing; protein processing; proteolysis; peptide biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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