NF-kappaB Inhibitor, SN50

Background: This peptide contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-kappaB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 inhibits translocation of the NF-kappaB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-kappaB nuclear translocation was 88% at 50 ug/ml (18 uM). In human monocytic THP-1 cells induced by LPS or TNFalpha there was 85% inhibition at 100 ug/ml.

Small volumes of NF-kappaB Inhibitor, SN50 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS842780 is a biochemical targeting NF-kappaB Inhibitor, SN50.