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PLX-4720

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842812

Background: PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC?? =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PLX-4720, Biochemical
Full Product Name
PLX-4720
Product Gene Name
PLX-4720 biochemical
Product Synonym Names
N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide
Form/Format
Appearance: White solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
413.83
CAS Number
918505-84-7
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD14635203
PubChem CID
24180719
Solubility/Reconstitution Instructions
DMSO (>80 mg/ml)
SMILES
CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
InChi
InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
InChi Key
YZDJQTHVDDOVHR-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for PLX-4720 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Raf Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Raf Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzyme Inhibitors (A-Z)

Structure of PLX-4720 biochemical

PLX-4720 Biochemical – Cat# MBS842812

Other Notes

Small volumes of PLX-4720 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLX-4720 purchase

MBS842812 is a biochemical targeting PLX-4720.
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