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IWP-4

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842840

Background: IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC?? = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IWP-4, Biochemical
Full Product Name
IWP-4
Product Gene Name
IWP-4 biochemical
Product Synonym Names
N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
Form/Format
Appearance: Crystaline solid
Purity/Purification
>=95% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
496.62
CAS Number
686772-17-8
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
Solubility/Reconstitution Instructions
DMSO (~2 mg/ml)
SMILES
O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5OC)=O
InChi
InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
InChi Key
RHUJMHOIQBDFQR-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for IWP-4 biochemical

Enzyme Inhibitors; Wnt Signaling InhibitorsBiochemicals; Enzyme Inhibitors; Wnt Signaling InhibitorsDiabetes; Obesity & Metabolic Syndrome; Signaling Pathways in Diabetes and Obesity; GSK-3/Wnt Signaling; Wnt/b-Catenin Signaling Pathway ModulatorsSignalin

Structure of IWP-4 biochemical

IWP-4 Biochemical – Cat# MBS842840

Other Notes

Small volumes of IWP-4 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IWP-4 purchase

MBS842840 is a biochemical targeting IWP-4.
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