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LY-411575

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842872

Background: LY411575 is a potent, cell-permeable gamma-secretase inhibitor (IC?? of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC?? of 0.39 nM. Notch inhibition using LY-411575 induces cochlear hair cell regeneration and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LY-411575, Biochemical
Full Product Name
LY-411575
Product Gene Name
LY-411575 biochemical
Product Synonym Names
N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide; LSN-411575
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 48 months
Molecular Weight
479.48
CAS Number
209984-57-6
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
10435235
Solubility/Reconstitution Instructions
DMSO (~ 5 mg/ml)
SMILES
CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
InChi
InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
InChi Key
ULSSJYNJIZWPSB-CVRXJBIPSA-N
Handling
Protect from air and light

Product Categories/Family for LY-411575 biochemical

Enzyme Inhibitors; Secretase InhibitorsBiochemicals; Enzyme Inhibitors; Secretase InhibitorsBiochemicals; Biochemicals (A-Z)

Structure of LY-411575 biochemical

LY-411575 Biochemical – Cat# MBS842872

Other Notes

Small volumes of LY-411575 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY-411575 purchase

MBS842872 is a biochemical targeting LY-411575.
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