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WZ4002

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842974

Background: A third generation EGFR inhibitor. Selectively inhibits mutant EGFR T790M. Inhibits EGFR phosphorylation and induces siginificant tumor regressionin murine model of EGFR T790M. WZ4002 can overcome anoikis resistance in EGFR-mutant lung… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
WZ4002, Biochemical
Full Product Name
WZ4002
Product Gene Name
WZ4002 biochemical
Product Synonym Names
N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
Form/Format
Appearance: Pale yellow solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
494.97
CAS Number
1213269-23-8
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
44607530
Solubility/Reconstitution Instructions
DMSO (~10 mg/ml)
SMILES
CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC
InChi
InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
InChi Key
ITTRLTNMFYIYPA-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for WZ4002 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of WZ4002 biochemical

WZ4002 Biochemical – Cat# MBS842974

Other Notes

Small volumes of WZ4002 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WZ4002 purchase

MBS842974 is a biochemical targeting WZ4002.
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