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SKPin C1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842976

Background: Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SKPin C1, Biochemical
Full Product Name
SKPin C1
Product Gene Name
SKPin C1 biochemical
Product Synonym Names
2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl-methyl)-2-thioxo-5-thiazolidinylidene]methyl]pheno-xy]acetic acid
Form/Format
Appearance: Yellow solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
465.34
CAS Number
432001-69-9
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
Solubility/Reconstitution Instructions
DMSO (15 mg/ml)
SMILES
BrC1=CC(/C=C2SC(N(CC3=CN=CC=C3)C\2=O)=S)=C(OCC(O)=O)C=C1
InChi
InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
InChi Key
IYCJJVVXEHZJHE-CHHVJCJISA-N
Handling
Protect from air and light

Product Categories/Family for SKPin C1 biochemical

Enzyme Inhibitors; Ubiquitin Ligase (E3) Inhibitors and Biochemicals; Enzyme Inhibitors; Ubiquitin Ligase (E3) Inhibitors Epigenetics; Writer Enzymes; Ubiquitin E2 Conjugases and Ubiquitin E3 Ligases; Ubiquitin Ligase (E3) Inhibitors and Biochemicals; Bio

Structure of SKPin C1 biochemical

SKPin C1 Biochemical – Cat# MBS842976

Other Notes

Small volumes of SKPin C1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SKPin C1 purchase

MBS842976 is a biochemical targeting SKPin C1.
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