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MLN8237

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842989

Background: MLN8237 is a potent and selective inhibitor of Aurora kinase A (IC?? =1.2 nM). It displays >200-fold higher selectivity for Aurora kinase A over Aurora kinase B. Displays antineoplastic activity. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MLN8237, Biochemical
Full Product Name
MLN8237
Product Gene Name
MLN8237 biochemical
Product Synonym Names
4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib
Form/Format
Appearance: Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
518.9
CAS Number
1028486-01-2
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
24771867
Solubility/Reconstitution Instructions
DMSO (>40 mg/ml)
SMILES
 COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
InChi
InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
InChi Key
ZLHFILGSQDJULK-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for MLN8237 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Aurora Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Aurora Kinase InhibitorsBiochemicals; Biochemicals (A-Z)

Structure of MLN8237 biochemical

MLN8237 Biochemical – Cat# MBS842989

Other Notes

Small volumes of MLN8237 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLN8237 purchase

MBS842989 is a biochemical targeting MLN8237.
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