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DAPT

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS842994

Background: Cell permeable. A potent inhibitor of gamma-secretase (IC?? = 115 nM for total beta-amyloid, IC?? = 200 nM for beta-amyloid 1-42). It reduces Abeta levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DAPT, Biochemical
Full Product Name
DAPT
Product Gene Name
DAPT biochemical
Product Synonym Names
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
432.46
CAS Number
208255-80-5
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD04974585
PubChem CID
5311272
Solubility/Reconstitution Instructions
DMSO (~20 mg/ml)
SMILES
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChi
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChi Key
DWJXYEABWRJFSP-XOBRGWDASA-N
Handling
Protect from air and moisture

Product Categories/Family for DAPT biochemical

Biochemicals; Enzyme Inhibitors; Secretase Inhibitors and; Stem Cell Research Tools; Stem Cell Fate Regulators; DifferentiationBiochemicals (A-Z)

Structure of DAPT biochemical

DAPT Biochemical – Cat# MBS842994

Other Notes

Small volumes of DAPT biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DAPT purchase

MBS842994 is a biochemical targeting DAPT.
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