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Smo Antagonist, SA1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843128

Background: A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC?? = 3.1 uM). Also inhibits the localization of Smo to cilia. Treatment… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Smo Antagonist, SA1, Biochemical
Full Product Name
Smo Antagonist, SA1
Product Synonym Names
3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Form/Format
Appearance: Crystalline solid
Purity/Purification
>=95% by NMR
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
448.53
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
5308963
Solubility/Reconstitution Instructions
DMSO
SMILES
CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi
InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key
UTURPAUEBUIDJO-UHFFFAOYSA-N
Handling
Protect from air and moisture

Product Categories/Family for Smo Antagonist, SA1 biochemical

Enzyme Inhibitors; Hedgehog (Hh) Signaling Pathway Antagonists and Biochemicals; Enzyme Inhibitors; Hedgehog (Hh) Signaling Pathway Antagonists and Biochemicals (A-Z)

Structure of Smo Antagonist, SA1 biochemical

Smo Antagonist, SA1 Biochemical – Cat# MBS843128

Other Notes

Small volumes of Smo Antagonist, SA1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Smo Antagonist, SA1 purchase

MBS843128 is a biochemical targeting Smo Antagonist, SA1.
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