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GDC-0449

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843144

Background: A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDC-0449, Biochemical
Full Product Name
GDC-0449
Product Gene Name
GDC-0449 biochemical
Product Synonym Names
2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
421.3
CAS Number
879085-55-9
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD12407408
PubChem CID
24776445
Solubility/Reconstitution Instructions
DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
SMILES
CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChi
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChi Key
BPQMGSKTAYIVFO-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for GDC-0449 biochemical

Biochemicals; Enzyme Inhibitors; Sonic Hedgehog (Shh) Signaling Pathway Antagonists and Stem Cell Research Tools; Stem Cell Signaling Pathways; Wnt/Hedgehog/Notch Signaling; Inhibitors and Biochemicals (A-Z)

Structure of GDC-0449 biochemical

GDC-0449 Biochemical – Cat# MBS843144

Other Notes

Small volumes of GDC-0449 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDC-0449 purchase

MBS843144 is a biochemical targeting GDC-0449.
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