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XL019

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843170

Background: XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC?? = 2.2 nM). Inhibits JAK1 (IC?? = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC?? = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
XL019, Biochemical
Full Product Name
XL019
Product Gene Name
XL019 biochemical
Product Synonym Names
(S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide
Form/Format
Appearance: Light yellow to light brown solid
Purity/Purification
>98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
444.53
CAS Number
945755-56-6
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
57990869
Solubility/Reconstitution Instructions
DMSO (~ 15 mg/ml)
SMILES
C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
InChi
InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1
InChi Key
ISOCDPQFIXDIMS-QHCPKHFHSA-N
Handling
Protect from air and light

Product Categories/Family for XL019 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Epigenetics; Writer Enzymes; Kinases; Kinase Inhibitors; JAK2 Inhibitor

Structure of XL019 biochemical

XL019 Biochemical – Cat# MBS843170

Other Notes

Small volumes of XL019 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XL019 purchase

MBS843170 is a biochemical targeting XL019.
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