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Jervine

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843173

Background: Cell-permeable. Structurally similar to cyclopamine. Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine is a useful negative… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Jervine, Biochemical
Full Product Name
Jervine
Product Synonym Names
(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1-1bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexad-ecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H--benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1-H)-one
Form/Format
Appearance: White to off-white solid
Purity/Purification
>=98% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
425.6
CAS Number
469-59-0
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD01684066
PubChem CID
10098
Solubility/Reconstitution Instructions
DMSO (5 mg/ml) or EtOH (10 mg/ml)
SMILES
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1
InChi
InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
InChi Key
CLEXYFLHGFJONT-DNMILWOZSA-N
Handling
Protect from air and moisture

Product Categories/Family for Jervine biochemical

Enzyme Inhibitors; Hedgehog (Hh) Signaling Pathway Antagonists and Biochemicals; Enzyme Inhibitors; Hedgehog (Hh) Signaling Pathway Antagonists and Signaling Pathways; Hedgehog (Hh) Signaling; Hedgehog (Hh) Signaling Pathway Antagonists and Biochemicals;

Structure of Jervine biochemical

Jervine Biochemical – Cat# MBS843173

Other Notes

Small volumes of Jervine biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Jervine purchase

MBS843173 is a biochemical targeting Jervine.
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