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Crizotinib

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843184

Background: A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Crizotinib, Biochemical
Full Product Name
Crizotinib
Product Synonym Names
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Form/Format
Appearance: Off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
450.34
CAS Number
877399-52-5
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD12407409
PubChem CID
11626560
Solubility/Reconstitution Instructions
DMSO
SMILES
CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChi
InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChi Key
KTEIFNKAUNYNJU-GFCCVEGCSA-N
Handling
Protect from air and light

Product Categories/Family for Crizotinib biochemical

Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase Inhibitors and Biochemicals (A-Z)

Structure of Crizotinib biochemical

Crizotinib Biochemical – Cat# MBS843184

Other Notes

Small volumes of Crizotinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Crizotinib purchase

MBS843184 is a biochemical targeting Crizotinib.
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