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PF-573228

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843219

Background: PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC?? = 4 nM). PF-573,228 inhibits FAK phosphorylation on Tyr(397) with an IC?? of 30-100 nM.  Displays 50 - 250-fold selectivity for FAK over other protein kinases.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PF-573228, Biochemical
Full Product Name
PF-573228
Product Gene Name
PF-573228 biochemical
Product Synonym Names
3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
Form/Format
Appearance: Off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
491.49
CAS Number
869288-64-2
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
yes
MDL Number
MFCD11519967
PubChem CID
11612883
Solubility/Reconstitution Instructions
DMSO (>40 mg/ml)
SMILES
CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
InChi
InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)
InChi Key
HESLKTSGTIBHJU-UHFFFAOYSA-N
Handling
Protect from air and light

Product Categories/Family for PF-573228 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsEnzyme Inhibitors; Enzyme Inhibitors (A-Z) Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Kinase InhibitorsBiochemicals; Enzyme Inhibitors; Enzym

Structure of PF-573228 biochemical

PF-573228 Biochemical – Cat# MBS843219

Other Notes

Small volumes of PF-573228 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-573228 purchase

MBS843219 is a biochemical targeting PF-573228.
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