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SIRT2 Inhibitor, AGK2 (AGK2)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843245

Background: A potent inhibitor of sirtuin 2 (SIRT2) (IC?? = 3.5 uM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SIRT2 Inhibitor, AGK2, Biochemical
Full Product Name
SIRT2 Inhibitor, AGK2
Product Synonym Names
AGK2; (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Form/Format
Appearance: Yellow solid
Purity/Purification
>=95% by HPLC
Preparation and Storage
4 degree C
Shelf Life: 24 months
Molecular Weight
434.27
CAS Number
304896-28-4
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD01909444
PubChem CID
2130404
Solubility/Reconstitution Instructions
DMSO
SMILES
C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
InChi
InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
InChi Key
SVENPFFEMUOOGK-SDNWHVSQSA-N
Handling
Protect from air and light

Structure of SIRT2 Inhibitor, AGK2 biochemical

SIRT2 Inhibitor, AGK2 Biochemical – Cat# MBS843245

Other Notes

Small volumes of SIRT2 Inhibitor, AGK2 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS843245 is a biochemical targeting SIRT2 Inhibitor, AGK2.
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