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NSC 66811

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843278

Background: Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro. More details

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Product Documentation
PDF
Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NSC 66811, Biochemical
Full Product Name
NSC 66811
Product Gene Name
Product Synonym Names
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Form/Format
Appearance: White solid
Purity/Purification
>=97% by HPLC
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
340.42
CAS Number
6964-62-1
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
248986
Solubility/Reconstitution Instructions
DMSO (~ 100 mM)
SMILES
CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
InChi
InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChi Key
WEENRMPCSWFMTE-UHFFFAOYSA-N
Handling
Protect from air and light

Other Notes

Small volumes of NSC 66811 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NSC 66811 purchase

MBS843278 is a biochemical targeting NSC 66811.
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