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KN-62

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843290

Background: Cell-permeable. KN-62 is a selective inhibitor of Ca?/calmodulin-dependent kinase type II (CaMKII; IC??= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
KN-62, Biochemical
Full Product Name
KN-62
Product Gene Name
KN-62 biochemical
Product Synonym Names
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 5-isoquinolinesulfonic acid
Form/Format
Appearance: Pale yellow solid
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Molecular Weight
721.84
CAS Number
127191-97-3
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD00083180
PubChem CID
5312126
Solubility/Reconstitution Instructions
DMSO (>50 mg/ml)
SMILES
CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
InChi
InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
InChi Key
RJVLFQBBRSMWHX-DHUJRADRSA-N
Handling
Protect from air and light

Product Categories/Family for KN-62 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; CaM Kinase Inhibitors and Biochemicals; Enzyme Inhibitors; Protein Kinase Inhibitors; CaM Kinase Inhibitors and Biochemicals; Biochemicals (A-Z)

Structure of KN-62 biochemical

KN-62 Biochemical – Cat# MBS843290

Other Notes

Small volumes of KN-62 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KN-62 purchase

MBS843290 is a biochemical targeting KN-62.
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