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GSK-J4 (Free base)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS843306

Background: GSK- J4 is cell-permeable ethyl ester of GSK-J1. Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC?? = 9 muM for the… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSK-J4, Biochemical
Full Product Name
GSK-J4 (Free base)
Product Gene Name
GSK-J4 biochemical
Product Synonym Names
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester
Form/Format
Appearance: Yellow waxy solid
Purity/Purification
>=99% by TLC
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Molecular Weight
417.5
CAS Number
1373423-53-0
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Y
MDL Number
MFCD22683852
PubChem CID
71729975
Solubility/Reconstitution Instructions
DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)
SMILES
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
InChi
InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
InChi Key
WBKCKEHGXNWYMO-UHFFFAOYSA-N
Handling
Protect from light and moisture

Product Categories/Family for GSK-J4 biochemical

Enzyme Inhibitors; Histone Demethylase (HDM) InhibitorsBiochemicals; Enzyme Inhibitors; Histone Demethylase (HDM) InhibitorsEpigenetics; Eraser Enzymes; Histone Demethylases (HDMs); HDM InhibitorsEpigenetics; Epigenetic Modulators (A-Z) Biochemicals; Bioc

Structure of GSK-J4 biochemical

GSK-J4 (Free base) Biochemical – Cat# MBS843306

Other Notes

Small volumes of GSK-J4 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK-J4 purchase

MBS843306 is a biochemical targeting GSK-J4. Also known as GSK-J4 (Free base).
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