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MIG (CXCL9) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844169

Background: Human MIG (monokine induced by interferon gamma) is produced by microphages and other cells. It is a member of the alpha chemokine family (C-X-C) of cytokines. MIG acts as a chemoattractant toward monocytes, lymphocytes, and certain T cells. Human… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MIG (CXCL9), Active Protein
Full Product Name
MIG, human recombinant
Product Gene Name
CXCL9 active protein
Product Synonym Names
Monokine Induced by Interferon-gamma; CXCL9; Gamma-interferon-induced monokine; Small-inducible cytokine B9
Host
E Coli
Form/Format
Sterile filtered and then lyophilized with no additives
Appearance: Lyophilized protein
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
11.7 kDa
OMIM
601704
3D Structure
ModBase 3D Structure for Q07325
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 1 mg/ml. The solution can be diluted into other buffered solutions or store at -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
The ED?? range = 10 -100 ng/ml, determined by the dose dependent chemotaxis with human lymphocytes cultured in the presence of IL-2.
Results
10 -100 ng/ml
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for CXCL9 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for CXCL9 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of CXCL9 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL9 purchase

MBS844169 is an active protein targeting CXCL9. Also known as MIG, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL9. It may not necessarily be applicable to this product.

NCBI GI #
4505187
NCBI GeneID
4283
NCBI Accession #
NP_002407.1
UniProt Primary Accession #
Q07325
UniProt Secondary Accession #
Q503B4
UniProt Related Accession #
Q07325
GenBank Nucleotide #
NM_002416.2
NCBI Official Full Name
C-X-C motif chemokine 9
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 9
NCBI Official Symbol
CXCL9
NCBI Official Synonym Symbols
CMK; MIG; Humig; SCYB9; crg-10
UniProt Protein Name
C-X-C motif chemokine 9
UniProt Synonym Protein Names
Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; HuMIG; MIG; Small-inducible cytokine B9
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL9
UniProt Synonym Gene Names
CMK; MIG; SCYB9; HuMIG; MIG
UniProt Entry Name
CXCL9_HUMAN
NCBI Protein Information
C-X-C motif chemokine 9

NCBI Summary for CXCL9

This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

UniProt Comments for CXCL9

CXCL9: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: protein binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; defense response; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; positive regulation of myoblast differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; cellular defense response; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; defense response to virus
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Research Articles on CXCL9

1. CXCL9 inhibits the proliferation of epithelial cells via phosphorylation of p70S6K, resulting in the excretion of TGF-beta as downstream mediator. CXCL9/CXCR3 interaction can exacerbate antineoplastic agent-induced intestinal damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL9 active protein

 Reference Product  PubMed Publications
 CXCR3 active protein  >493 publications with CXCL9 and CXCR3
 CCL5 active protein  >254 publications with CXCL9 and CCL5
 CCR5 active protein  >86 publications with CXCL9 and CCR5
 CXCL12 active protein  >76 publications with CXCL9 and CXCL12
 CCL20 active protein  >58 publications with CXCL9 and CCL20
 CCL21 active protein  >37 publications with CXCL9 and CCL21
 CCR3 active protein  >30 publications with CXCL9 and CCR3
 IL8 active protein  >24 publications with CXCL9 and IL8
 CXCL6 active protein  >15 publications with CXCL9 and CXCL6
 PF4 active protein  >5 publications with CXCL9 and PF4

Diseases associated with CXCL9 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >444 publications with CXCL9 and Inflammation
 Necrosis Antibodies  >225 publications with CXCL9 and Necrosis
 Disease Models, Animal Antibodies  >166 publications with CXCL9 and Disease Models, Animal
 Lung Diseases Antibodies  >126 publications with CXCL9 and Lung Diseases
 Liver Diseases Antibodies  >94 publications with CXCL9 and Liver Diseases
 Cardiovascular Diseases Antibodies  >63 publications with CXCL9 and Cardiovascular Diseases
 Fibrosis Antibodies  >63 publications with CXCL9 and Fibrosis
 Hypersensitivity Antibodies  >60 publications with CXCL9 and Hypersensitivity
 Neoplasms, Experimental Antibodies  >59 publications with CXCL9 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >36 publications with CXCL9 and Kidney Diseases

Organs/Tissues associated with CXCL9 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >858 publications with CXCL9 and Blood
 Lung Antibodies  >176 publications with CXCL9 and Lung
 Skin Antibodies  >148 publications with CXCL9 and Skin
 Liver Antibodies  >126 publications with CXCL9 and Liver
 Brain Antibodies  >106 publications with CXCL9 and Brain
 Lymph Node Antibodies  >96 publications with CXCL9 and Lymph Node
 Spleen Antibodies  >83 publications with CXCL9 and Spleen
 Kidney Antibodies  >76 publications with CXCL9 and Kidney
 Heart Antibodies  >56 publications with CXCL9 and Heart
 Intestine Antibodies  >39 publications with CXCL9 and Intestine
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