Il-18 (IL18) Active Protein

Name: IL18 Active Protein; Il-18; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844186
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844186

Background: Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-18 (IL18), Active Protein

Full Product Name

IL-18, human recombinant

Product Gene Name

IL18 active protein

Product Synonym Names

Interferon-gamma-inducing factor; IGIF; IL-1g; IL-18; IL1F4; MGC12320; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin.

Host

E Coli

Form/Format

Sterile filtered and lyophilized from PBS
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

18.3 kDa

OMIM

600953

3D Structure

ModBase 3D Structure for Q14116

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in ice-cold H?O to a concentration of 0.5-1 ug/ul. The solution can be stored at 4 degree C for 1 week. For storage, prepare appropriate aliquots and freeze them at -80 degree C for future use.

Endotoxin Level

<0.1 ng/mug

Biological Activity

The ED?? as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/ml.

Results

5 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for IL18 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IL18 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL18 purchase

MBS844186 is an active protein targeting IL18. Also known as IL-18, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.

NCBI GI #

342349321

NCBI GeneID

3606

NCBI Accession #

NP_001230140.1

UniProt Primary Accession #

Q14116

UniProt Secondary Accession #

O75599; Q6FGY3; Q6WWJ7

UniProt Related Accession #

Q14116

GenBank Nucleotide #

NM_001243211.1

NCBI Official Full Name

interleukin-18 isoform 2 proprotein

NCBI Official Synonym Full Names

interleukin 18

NCBI Official Symbol

IL18

NCBI Official Synonym Symbols

IGIF; IL-18; IL-1g; IL1F4

UniProt Protein Name

Interleukin-18

UniProt Synonym Protein Names

Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma

Protein Family

Interleukin

UniProt Gene Name

IL18

UniProt Synonym Gene Names

IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma

UniProt Entry Name

IL18_HUMAN

NCBI Protein Information

interleukin-18

NCBI Summary for IL18

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

UniProt Comments for IL18

IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 11q22.2-q22.3

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; positive regulation of natural killer cell proliferation; T-helper 1 type immune response; T-helper 2 type immune response; interleukin-2 biosynthetic process; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response

Research Articles on IL18

1. The results showed that there was no evidence for an association between the HCV infections and the polymorphisms genotypes of IL-18. However, plasma IL-18 levels were found higher in HCV infection patients than in healthy controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL18 active protein

Reference Product	PubMed Publications
CASP1 active protein	>566 publications with IL18 and CASP1
IL10 active protein	>315 publications with IL18 and IL10
IL18R1 active protein	>225 publications with IL18 and IL18R1
IL13 active protein	>93 publications with IL18 and IL13
IL6 active protein	>83 publications with IL18 and IL6
IL1B active protein	>47 publications with IL18 and IL1B
IL18RAP active protein	>37 publications with IL18 and IL18RAP
IFNG active protein	>28 publications with IL18 and IFNG
IL18BP active protein	>19 publications with IL18 and IL18BP
NFKB1 active protein	>4 publications with IL18 and NFKB1

Pathways associated with IL18 active protein

Products by Pathway	Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
Cellular Roles Of Anthrax Toxin Pathway antibodies	Cellular Roles Of Anthrax Toxin Pathway Diagram
Corticotropin-releasing Hormone Pathway antibodies	Corticotropin-releasing Hormone Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram

Diseases associated with IL18 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1297 publications with IL18 and Inflammation
Necrosis Antibodies	>835 publications with IL18 and Necrosis
Cardiovascular Diseases Antibodies	>460 publications with IL18 and Cardiovascular Diseases
Kidney Diseases Antibodies	>330 publications with IL18 and Kidney Diseases
Hypersensitivity Antibodies	>279 publications with IL18 and Hypersensitivity
Arthritis, Rheumatoid Antibodies	>226 publications with IL18 and Arthritis, Rheumatoid
Heart Diseases Antibodies	>219 publications with IL18 and Heart Diseases
Hypersensitivity, Immediate Antibodies	>196 publications with IL18 and Hypersensitivity, Immediate
Neoplasms, Experimental Antibodies	>128 publications with IL18 and Neoplasms, Experimental
Fibrosis Antibodies	>90 publications with IL18 and Fibrosis

Organs/Tissues associated with IL18 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>429 publications with IL18 and Liver
Lung Antibodies	>329 publications with IL18 and Lung
Heart Antibodies	>240 publications with IL18 and Heart
Bone Antibodies	>227 publications with IL18 and Bone
Skin Antibodies	>227 publications with IL18 and Skin
Brain Antibodies	>224 publications with IL18 and Brain
Intestine Antibodies	>176 publications with IL18 and Intestine
Bone Marrow Antibodies	>153 publications with IL18 and Bone Marrow
Muscle Antibodies	>142 publications with IL18 and Muscle
Connective Tissue Antibodies	>77 publications with IL18 and Connective Tissue