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MCP-2 (CCL8) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844196

Background: Macrophage/monocyte chemotactic protein-2 (MCP-2) plays an important role in the inflammatory response of blood monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. Recombinant murine MCP-2 is an 8.5 kDa protein… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MCP-2 (Ccl8), Active Protein
Full Product Name
MCP-2, murine recombinant
Product Gene Name
Product Synonym Names
Monocyte Chemotactic Protein-2; CCL8; HC14; Small-inducible cytokine A8
Host
E Coli
Form/Format
Sterile filtered and then lyophilized with no additives
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
8.5 kDa
3D Structure
ModBase 3D Structure for Q9Z121
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100 ng/ml.
Results
10-100 ng/ml.
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for Ccl8 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of Ccl8 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ccl8 purchase

MBS844196 is an active protein targeting Ccl8. Also known as MCP-2, murine recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Ccl8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
C-C motif chemokine 8
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 8
NCBI Official Symbol
Ccl8
NCBI Official Synonym Symbols
HC14; Mcp2; MCP-2; Scya8; AB023418; 1810063B20Rik
UniProt Protein Name
C-C motif chemokine 8
UniProt Synonym Protein Names
Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8
Protein Family
UniProt Gene Name
Ccl8
UniProt Synonym Gene Names
Mcp2; Scya8; MCP-2
UniProt Entry Name
CCL8_MOUSE
NCBI Protein Information
C-C motif chemokine 8

UniProt Comments for Ccl8

CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; chemokine activity; cytokine activity

Biological Process: immune response; chemotaxis; inflammatory response; positive regulation of myoblast differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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