DUSP21 Active Protein

Name: DUSP21 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844230
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844230

Background: DuSP21 (Dual specificity protein phosphatase 21) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases (DuSPs) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DUSP21, Active Protein

Full Product Name

DUSP21, human recombinant

Product Gene Name

DUSP21 active protein

Product Synonym Names

Dual specificity protein phosphatase 21

Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTASAS SFSSSQGVQQ PSIYSFSQIT RSLFLSNGVA ANDKLLLSSN RITAIVNASV EVVNVFFEGI QYIKVPVTDA RDSRLYDFFD PIADLIHTID MRQGRTLLHC MAGVSRSASL CLAYLMKYHS MSLLDAHTWT KSRRPIIRPN NGFWEQLINY EFKLFNNNTV RMINSPVGNI PDIYEKDLRM MISM

Host

E Coli

Form/Format

0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 200 mM NaCl and 2 mM DTT
Appearance: Liquid

Purity/Purification

>=90%

Concentration

0.25 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

24.1 kDa (214 aa, 1-190 aa + His Tag)

OMIM

300678

3D Structure

ModBase 3D Structure for Q9H596

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 1800 unit/mg. Enzymatic activity was confirmed by measuring the amount of enzyme hydrolyzing 1 nmole of p-nitrophenyl phosphate (pNPP) per minute at 37 degree C, pH7.5 using 10 mM of substrate.

Results

Specific activity is > 1800 unit/mg

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for DUSP21 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for DUSP21 active protein

SDS-PAGE

Other Notes

Small volumes of DUSP21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP21 purchase

MBS844230 is an active protein targeting DUSP21. Also known as DUSP21, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP21. It may not necessarily be applicable to this product.

NCBI GI #

225703077

NCBI GeneID

63904

NCBI Accession #

NP_071359.3

UniProt Primary Accession #

Q9H596

UniProt Secondary Accession #

Q0VDA6; Q6IAJ6; Q6YDQ8

UniProt Related Accession #

Q9H596

GenBank Nucleotide #

NM_022076.3

NCBI Official Full Name

dual specificity protein phosphatase 21

NCBI Official Synonym Full Names

dual specificity phosphatase 21

NCBI Official Symbol

DUSP21

NCBI Official Synonym Symbols

LMWDSP21

UniProt Protein Name

Dual specificity protein phosphatase 21

UniProt Synonym Protein Names

Low molecular weight dual specificity phosphatase 21; LMW-DSP21

Protein Family

Dual specificity phosphatase

UniProt Gene Name

DUSP21

UniProt Synonym Gene Names

LMWDSP21; LMW-DSP21

UniProt Entry Name

DUS21_HUMAN

NCBI Protein Information

dual specificity protein phosphatase 21

NCBI Summary for DUSP21

This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]

UniProt Comments for DUSP21

DUSP21: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.16; Motility/polarity/chemotaxis; Mitochondrial; EC 3.1.3.48

Chromosomal Location of Human Ortholog: Xp11.4-p11.23

Cellular Component: mitochondrial matrix; cytoplasm; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: inactivation of MAPK activity

Research Articles on DUSP21

1. DUSP21 plays an important role in sustaining hepatocellular carcinoma (HCC) cell proliferation and may thus act as a potential therapeutic target in HCC treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with DUSP21 active protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>1 publications with DUSP21 and Carcinoma
Liver Neoplasms Antibodies	>1 publications with DUSP21 and Liver Neoplasms

Organs/Tissues associated with DUSP21 active protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>2 publications with DUSP21 and Testis