CD84/SLAMF5 (CD84) Active Protein

Name: CD84 Active Protein; CD84/SLAMF5; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844234
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844234

Background: Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contain one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD84/SLAMF5, Active Protein

Full Product Name

Human CellExp CD84 / SLAMF5, human recombinant

Product Gene Name

CD84 active protein

Product Synonym Names

CD84; SLAMF5; LY9B; SLAMF5; hCD84; mCD84

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.6 kDa. The predicted N-terminus is Lys 22. DTT-reduced Protein migrates as 35-45 kDa due to glycosylation.

OMIM

604513

3D Structure

ModBase 3D Structure for Q9UIB8

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured in a cell proliferation assay using PHA stimulated human T cells in the presence of anti-CD3. The ED50 for this effect is typically 2-6 ug/ml in the presence of anti-CD3 immobilized at 20 ng/ml.

Results

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for CD84 active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and E

Applications Tested/Suitable for CD84 active protein

SDS-PAGE

Other Notes

Small volumes of CD84 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD84 purchase

MBS844234 is an active protein targeting CD84. Also known as Human CellExp CD84 / SLAMF5, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD84. It may not necessarily be applicable to this product.

NCBI GI #

296434285

NCBI GeneID

8832

NCBI Accession #

NP_001171808.1

UniProt Primary Accession #

Q9UIB8

UniProt Secondary Accession #

O15430; O95266; O95660; Q5H9R1; Q6FHA8; Q8WLP1; Q8WWI8; Q9UF04; Q9UIB6; B2R8T1; B7Z3R8

UniProt Related Accession #

Q9UIB8

GenBank Nucleotide #

NM_001184879.1

NCBI Official Full Name

SLAM family member 5 isoform 1

NCBI Official Synonym Full Names

CD84 molecule

NCBI Official Symbol

CD84

NCBI Official Synonym Symbols

LY9B; hCD84; mCD84; SLAMF5

UniProt Protein Name

SLAM family member 5

UniProt Synonym Protein Names

Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD_antigen: CD84

Protein Family

SLAM family

UniProt Gene Name

CD84

UniProt Synonym Gene Names

SLAMF5

UniProt Entry Name

SLAF5_HUMAN

NCBI Protein Information

SLAM family member 5

NCBI Summary for CD84

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

UniProt Comments for CD84

CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: defense response; homophilic cell adhesion; blood coagulation; leukocyte migration

Research Articles on CD84

1. up-regulated in Kawasaki disease arteriopathy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD84 active protein

Reference Product	PubMed Publications
CD2 active protein	>25 publications with CD84 and CD2
CD48 active protein	>23 publications with CD84 and CD48
SH2D1A active protein	>18 publications with CD84 and SH2D1A
SH2D1B active protein	>4 publications with CD84 and SH2D1B
PTPN11 active protein	>2 publications with CD84 and PTPN11

Diseases associated with CD84 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>3 publications with CD84 and Inflammation
Neoplasms, Experimental Antibodies	>2 publications with CD84 and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>2 publications with CD84 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>2 publications with CD84 and Nervous System Diseases
Necrosis Antibodies	>2 publications with CD84 and Necrosis
Adenocarcinoma Antibodies	>1 publications with CD84 and Adenocarcinoma
Asthma Antibodies	>1 publications with CD84 and Asthma
Liver Neoplasms Antibodies	>1 publications with CD84 and Liver Neoplasms
Disease Models, Animal Antibodies	>1 publications with CD84 and Disease Models, Animal

Organs/Tissues associated with CD84 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>52 publications with CD84 and Blood
Bone Antibodies	>10 publications with CD84 and Bone
Spleen Antibodies	>7 publications with CD84 and Spleen
Lymph Node Antibodies	>6 publications with CD84 and Lymph Node
Lymph Antibodies	>4 publications with CD84 and Lymph
Tonsil Antibodies	>4 publications with CD84 and Tonsil
Pharynx Antibodies	>3 publications with CD84 and Pharynx
Liver Antibodies	>3 publications with CD84 and Liver
Testis Antibodies	>1 publications with CD84 and Testis
Intestine Antibodies	>1 publications with CD84 and Intestine