Human Cellexp CTSD Active Protein – Cat# MBS844250

Cathepsin D (CTSD) Human Cellexp Active Protein

Name: CTSD Active Protein; Cathepsin D; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS844250
Price: 420 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844250

Background: Cathepsin D is also known as CTSD, CPSD, which belongs to the peptidase A1 family. Cathepsin D can be cleaved into the following 2 chains: cathepsin D light chain and cathepsin D heavy chain, which is expressed in the aorta extracellular space (at… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cathepsin D (CTSD), Active Protein

Full Product Name

Human CellExp Cathepsin D, human recombinant

Product Gene Name

CTSD active protein

Product Synonym Names

CTSD; Cathepsin D; CPSD; CLN10

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in 50 mM MES, pH 6.5 with 100 mM NaCl. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 43.6 kDa. The predicted N-terminus is Ser 19. DTT-reduced Protein migrates as 45-55 kDa due to glycosylation.

OMIM

116840

3D Structure

ModBase 3D Structure for P07339

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >450 pmol/min/ug.

Results

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >450 pmol/min/ug.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for CTSD active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Proteases; CathepsinsApoptosis & Related Products; Non-Caspase Proteases; Cathepsin; Cathepsin Enzymes

Applications Tested/Suitable for CTSD active protein

SDS-PAGE

Other Notes

Small volumes of CTSD active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSD purchase

MBS844250 is an active protein targeting CTSD. Also known as Human CellExp Cathepsin D, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSD. It may not necessarily be applicable to this product.

NCBI GI #

4503143

NCBI GeneID

1509

NCBI Accession #

NP_001900.1

UniProt Primary Accession #

P07339

UniProt Secondary Accession #

Q6IB57

UniProt Related Accession #

P07339

GenBank Nucleotide #

NM_001909.4

NCBI Official Full Name

cathepsin D preproprotein

NCBI Official Synonym Full Names

cathepsin D

NCBI Official Symbol

CTSD

NCBI Official Synonym Symbols

CPSD; CLN10; HEL-S-130P

UniProt Protein Name

Cathepsin D

Protein Family

Aspartic-type endopeptidase

UniProt Gene Name

CTSD

UniProt Synonym Gene Names

CPSD

UniProt Entry Name

CATD_HUMAN

NCBI Protein Information

cathepsin D

NCBI Summary for CTSD

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

UniProt Comments for CTSD

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: Protease; Autophagy; Motility/polarity/chemotaxis; EC 3.4.23.5

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; lysosome; melanosome; extracellular region

Molecular Function: protein binding; aspartic-type endopeptidase activity

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10

Research Articles on CTSD

1. These results suggest that decreased expression of cathepsin D in the peripheral monocytes is a potential signature of Alzheimer disease,and that this decreased expression is involved in Abeta degradation and Alzheimer disease pathogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTSD active protein

Reference Product	PubMed Publications
CTSB active protein	>33 publications with CTSD and CTSB
TP53 active protein	>5 publications with CTSD and TP53
CTSS active protein	>4 publications with CTSD and CTSS
CTSA active protein	>2 publications with CTSD and CTSA
BID active protein	>1 publications with CTSD and BID
ESR1 active protein	>1 publications with CTSD and ESR1

Pathways associated with CTSD active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Ceramide Signaling Pathway antibodies	Ceramide Signaling Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
LKB1 Signaling Events Pathway antibodies	LKB1 Signaling Events Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram

Diseases associated with CTSD active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>63 publications with CTSD and Nervous System Diseases
Disease Models, Animal Antibodies	>23 publications with CTSD and Disease Models, Animal
Breast Neoplasms Antibodies	>18 publications with CTSD and Breast Neoplasms
Inflammation Antibodies	>17 publications with CTSD and Inflammation
Necrosis Antibodies	>8 publications with CTSD and Necrosis
Neoplasm Invasiveness Antibodies	>8 publications with CTSD and Neoplasm Invasiveness
Cardiovascular Diseases Antibodies	>7 publications with CTSD and Cardiovascular Diseases
Fibrosis Antibodies	>6 publications with CTSD and Fibrosis
Liver Neoplasms Antibodies	>6 publications with CTSD and Liver Neoplasms
Seizures Antibodies	>5 publications with CTSD and Seizures

Organs/Tissues associated with CTSD active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>43 publications with CTSD and Blood
Brain Antibodies	>40 publications with CTSD and Brain
Liver Antibodies	>25 publications with CTSD and Liver
Muscle Antibodies	>21 publications with CTSD and Muscle
Lung Antibodies	>15 publications with CTSD and Lung
Kidney Antibodies	>12 publications with CTSD and Kidney
Eye Antibodies	>10 publications with CTSD and Eye
Vascular Antibodies	>9 publications with CTSD and Vascular
Bone Antibodies	>9 publications with CTSD and Bone
Skin Antibodies	>6 publications with CTSD and Skin