Human Cellexp DLL-4 Active Protein – Cat# MBS844261

Sdll-4 (DLL-4) Human Cellexp Active Protein

Name: DLL-4 Active Protein; Sdll-4; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS844261
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844261

Background: Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

sDLL-4, Active Protein

Full Product Name

Human CellExp sDLL-4, Human Recombinant

Product Gene Name

DLL-4 active protein

Product Synonym Names

Delta-like protein 4; Drosophila Delta homolog 4

Sequence

SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP

Host

HEK 293 cells

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.
Appearance: Lyophilized powder

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

54.3 kDa

OMIM

605185

3D Structure

ModBase 3D Structure for Q9NR61

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

The sDLL-4, when immobilized at concentrations > 1.5 mug/mL will inhibit myogenesis in C2C12 cells.

Biological Activity

The sDLL-4, when immobilized at concentrations > 1.5 mug/mL will inhibit myogenesis in C2C12 cells.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for DLL-4 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth

Applications Tested/Suitable for DLL-4 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of DLL-4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLL-4 purchase

MBS844261 is an active protein targeting DLL-4. Also known as Human CellExp sDLL-4, Human Recombinant. Host: HEK 293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for DLL-4. It may not necessarily be applicable to this product.

NCBI GI #

9506545

NCBI GeneID

54567

NCBI Accession #

NP_061947.1

UniProt Primary Accession #

Q9NR61

UniProt Secondary Accession #

Q3KP23; Q9NQT9

UniProt Related Accession #

Q9NR61

GenBank Nucleotide #

NM_019074.3

NCBI Official Full Name

delta-like protein 4

NCBI Official Synonym Full Names

delta-like 4 (Drosophila)

NCBI Official Symbol

DLL4

NCBI Official Synonym Symbols

hdelta2

UniProt Protein Name

Delta-like protein 4

UniProt Synonym Protein Names

Drosophila Delta homolog 4; Delta4

UniProt Gene Name

DLL4

UniProt Synonym Gene Names

Delta4

UniProt Entry Name

DLL4_HUMAN

NCBI Protein Information

delta-like protein 4

NCBI Summary for DLL-4

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

UniProt Comments for DLL-4

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: plasma membrane; integral to membrane

Molecular Function: calcium ion binding; Notch binding

Biological Process: patterning of blood vessels; negative regulation of cell proliferation; Notch signaling pathway; regulation of neurogenesis; visual perception; blood circulation; Notch receptor processing; blood vessel remodeling; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Research Articles on DLL-4

1. Dormant Dbf4 mRNA in immature GV oocytes is recruited by cytoplasmic polyadenylation during oocyte maturation and is dependent on MPF activity via its cytoplasmic polyadenylation element (CPE)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DLL-4 active protein

Reference Product	PubMed Publications
NOTCH1 active protein	>162 publications with DLL-4 and NOTCH1
DLL1 active protein	>71 publications with DLL-4 and DLL1
NOTCH4 active protein	>47 publications with DLL-4 and NOTCH4
NOTCH3 active protein	>35 publications with DLL-4 and NOTCH3
HEY1 active protein	>33 publications with DLL-4 and HEY1
ADAM10 active protein	>3 publications with DLL-4 and ADAM10
MIB1 active protein	>3 publications with DLL-4 and MIB1
EFNB2 active protein	>2 publications with DLL-4 and EFNB2

Pathways associated with DLL-4 active protein

Products by Pathway	Pathway Diagram
Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies	Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies	Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Of Signal Transduction Pathway antibodies	Diseases Of Signal Transduction Pathway Diagram
NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies	NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram

Diseases associated with DLL-4 active protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>40 publications with DLL-4 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>26 publications with DLL-4 and Neoplasms, Experimental
Inflammation Antibodies	>16 publications with DLL-4 and Inflammation
Breast Neoplasms Antibodies	>15 publications with DLL-4 and Breast Neoplasms
Lung Neoplasms Antibodies	>14 publications with DLL-4 and Lung Neoplasms
Liver Diseases Antibodies	>10 publications with DLL-4 and Liver Diseases
Kidney Diseases Antibodies	>10 publications with DLL-4 and Kidney Diseases
Hypertension Antibodies	>9 publications with DLL-4 and Hypertension
Necrosis Antibodies	>9 publications with DLL-4 and Necrosis
Atherosclerosis Antibodies	>6 publications with DLL-4 and Atherosclerosis

Organs/Tissues associated with DLL-4 active protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>292 publications with DLL-4 and Vascular
Brain Antibodies	>38 publications with DLL-4 and Brain
Lung Antibodies	>36 publications with DLL-4 and Lung
Muscle Antibodies	>35 publications with DLL-4 and Muscle
Eye Antibodies	>30 publications with DLL-4 and Eye
Heart Antibodies	>23 publications with DLL-4 and Heart
Placenta Antibodies	>15 publications with DLL-4 and Placenta
Intestine Antibodies	>12 publications with DLL-4 and Intestine
Kidney Antibodies	>11 publications with DLL-4 and Kidney
Ovary Antibodies	>9 publications with DLL-4 and Ovary