Human Cellexp KLK13 Active Protein – Cat# MBS844269

Kallikrein-13 (KLK13) Human Cellexp Active Protein

Name: KLK13 Active Protein; Kallikrein-13; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS844269
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844269

Background: Kallikrein-13 (KLK13) is also known as Kallikrein-like protein 4 (KLK-L4), is a secreted protein, belongs to the peptidase S1 family and Kallikrein subfamily. KLK-13 contains one peptidase S1 domain. KLK13 is mainly expressed in prostate, breast,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Kallikrein-13 (KLK13), Active Protein

Full Product Name

Human CellExp Kallikrein-13, human recombinant

Product Gene Name

KLK13 active protein

Product Synonym Names

KLK13; KLKL4; KLK-13; Kallikrein-13

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in 20 mM MES, 150 mM NaCl, pH 6.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with 6×his tag at the C-terminus, and has a calculated MW of 28 kDa. The predicted N-terminus is Gly 18. DTT-reduced Protein migrates as 33-40 kDa in SDS-PAGE due to glycosylation.

OMIM

605505

3D Structure

ModBase 3D Structure for Q9UKR3

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is > 150 pmoles / min / ug.

Results

Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is > 150 pmoles / min / ug.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for KLK13 active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Other Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for KLK13 active protein

SDS-PAGE

Other Notes

Small volumes of KLK13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLK13 purchase

MBS844269 is an active protein targeting KLK13. Also known as Human CellExp Kallikrein-13, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK13. It may not necessarily be applicable to this product.

NCBI GI #

11496281

NCBI GeneID

26085

NCBI Accession #

NP_056411.1

UniProt Primary Accession #

Q9UKR3

UniProt Secondary Accession #

Q86VI8; Q9Y433; A7UNK6

UniProt Related Accession #

Q9UKR3

GenBank Nucleotide #

NM_015596.1

NCBI Official Full Name

kallikrein-13

NCBI Official Synonym Full Names

kallikrein-related peptidase 13

NCBI Official Symbol

KLK13

NCBI Official Synonym Symbols

KLKL4; KLK-L4

UniProt Protein Name

Kallikrein-13

UniProt Synonym Protein Names

Kallikrein-like protein 4; KLK-L4

Protein Family

Kallikrein

UniProt Gene Name

KLK13

UniProt Synonym Gene Names

KLKL4; KLK-L4

UniProt Entry Name

KLK13_HUMAN

NCBI Protein Information

kallikrein-13

NCBI Summary for KLK13

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for KLK13

KLK13: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.-; Vesicle

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space; cytoplasm; extracellular region; secretory granule

Molecular Function: protein binding; hydrolase activity; serine-type endopeptidase activity

Biological Process: protein processing; proteolysis

Research Articles on KLK13

1. KLK13 may play an important role in regulating cellular migration and invasiveness, making the loss of KLK13 a potential biomarker for early detection of lymph node metastasis in oral squamous cell carcinomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KLK13 active protein

Reference Product	PubMed Publications
A2M active protein	>1 publications with KLK13 and A2M

Pathways associated with KLK13 active protein

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with KLK13 active protein

Disease Name	Pubmed Publications
Ovarian Diseases Antibodies	>6 publications with KLK13 and Ovarian Diseases
Lung Neoplasms Antibodies	>6 publications with KLK13 and Lung Neoplasms
Lung Diseases Antibodies	>5 publications with KLK13 and Lung Diseases
Death Antibodies	>4 publications with KLK13 and Death
Prostatic Diseases Antibodies	>2 publications with KLK13 and Prostatic Diseases
Inflammation Antibodies	>2 publications with KLK13 and Inflammation
Neoplasms, Experimental Antibodies	>1 publications with KLK13 and Neoplasms, Experimental
Birth Weight Antibodies	>1 publications with KLK13 and Birth Weight
Infertility, Male Antibodies	>1 publications with KLK13 and Infertility, Male
Necrosis Antibodies	>1 publications with KLK13 and Necrosis

Organs/Tissues associated with KLK13 active protein

Organ/Tissue Name	Pubmed Publications
Mouth Antibodies	>11 publications with KLK13 and Mouth
Testis Antibodies	>5 publications with KLK13 and Testis
Uncharacterized Tissue Antibodies	>1 publications with KLK13 and Uncharacterized Tissue