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Kallikrein 11 (KLK11) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2556701

Protein Construction: Recombinant Human Kallikrein 11 is produced by our Mammalian expression system and the target gene encoding Glu19-Asn250 is expressed with a 6His tag at the C-terminus.Background: Human Kallikrein 11 (KLK11) is a member of tissue… More details

$235 / 0.01 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Kallikrein 11 (KLK11), Active Protein
Full Product Name
Recombinant Human Kallikrein 11 Protein
Product Gene Name
Product Synonym Names
Kallikrein-11; hK11; Hippostasin; Serine Protease 20; Trypsin-Like Protease; KLK11; PRSS20; TLSP
Host
Human Cells
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM TrisHCl, 150mM NaCl, 2mM CaCl2, pH 8.0.
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Preparation and Storage
Store at < -20 degree C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Molecular Weight
Molecular Mass: 26.3kDa
Actual Protein Molecular Mass: 38kDa
3D Structure
ModBase 3D Structure for Q9UBX7
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fragment
Glu19-Asn250
Fusion Tag
C-6His
Activity
Measured by its ability to cleave a colorimetric peptide substrate D-Val-Leu-Lys-ThioBenzyl ester (VLK-SBzl), in the presence of 5,5'Dithio-bis (2-nitrobenzoic acid) (DTNB) (Edwards, K.M. et al.,1999, J. Biol. Chem. 274: 30468). The specific activity is >200 pmoles/min/mug.(Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KLK11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLK11 purchase

MBS2556701 is an active protein targeting KLK11. Also known as Recombinant Human Kallikrein 11 Protein. Host: Human Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kallikrein-11 isoform 1
NCBI Official Synonym Full Names
kallikrein related peptidase 11
NCBI Official Symbol
KLK11
NCBI Official Synonym Symbols
TLSP; PRSS20
UniProt Protein Name
Kallikrein-11
UniProt Synonym Protein Names
Hippostasin; Serine protease 20; Trypsin-like protease
Protein Family
UniProt Gene Name
KLK11
UniProt Synonym Gene Names
PRSS20; TLSP; hK11
NCBI Protein Information
kallikrein-11

NCBI Summary for KLK11

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
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UniProt Comments for KLK11

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KLK11 active protein

 Reference Product  PubMed Publications
 KLK10 active protein  >11 publications with KLK11 and KLK10
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