GDF-15-D (GDF-15) Active Protein

Name: GDF-15 Active Protein; GDF-15-D; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844290
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844290

Background: Growth and differentiation factor 15 (GDF-15) is a TGFbeta family member, made by in the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GDF-15-D, Active Protein

Full Product Name

GDF-15-D, human recombinant

Product Gene Name

GDF-15 active protein

Product Synonym Names

MIC-1; Placental TGFbeta; Prostate differentiation factor; MIC1; PDF; PLAB; PTGFB

Sequence

MARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI

Host

E Coli

Form/Format

Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

26.8 kDa

OMIM

605312

3D Structure

ModBase 3D Structure for Q99988

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 5 mM acetic acid at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.

Endotoxin Level

<0.01 ng/mug

Biological Activity

The activity is determined by the inhibition of DU-145 cells and is typically 1-2 ug/ml.

Results

1-2 ug/ml

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for GDF-15 active protein

Cytokines; Growth Factors & Hormones; GDFsProteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for GDF-15 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of GDF-15 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF-15 purchase

MBS844290 is an active protein targeting GDF-15. Also known as GDF-15-D, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF-15. It may not necessarily be applicable to this product.

NCBI GI #

153792495

NCBI GeneID

9518

NCBI Accession #

NP_004855.2

UniProt Primary Accession #

Q99988

UniProt Secondary Accession #

O14629; P78360; Q9BWA0; Q9NRT0

UniProt Related Accession #

Q99988

GenBank Nucleotide #

NM_004864.2

NCBI Official Full Name

growth/differentiation factor 15

NCBI Official Synonym Full Names

growth differentiation factor 15

NCBI Official Symbol

GDF15

NCBI Official Synonym Symbols

PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15

UniProt Protein Name

Growth/differentiation factor 15

UniProt Synonym Protein Names

Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor

UniProt Gene Name

GDF15

UniProt Synonym Gene Names

MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1

UniProt Entry Name

GDF15_HUMAN

NCBI Protein Information

growth/differentiation factor 15

NCBI Summary for GDF-15

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]

UniProt Comments for GDF-15

GDF15: disulfide-linked. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; cell-cell signaling; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; signal transduction; cell development

Research Articles on GDF-15

1. Growth Differentiation Factor 15 expression and regulation during erythroid differentiation in non-transfusion dependent thalassemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF-15 active protein

Reference Product	PubMed Publications
HAMP active protein	>47 publications with GDF-15 and HAMP
ATF3 active protein	>23 publications with GDF-15 and ATF3
EGR1 active protein	>16 publications with GDF-15 and EGR1
TP53 active protein	>13 publications with GDF-15 and TP53
SP1 active protein	>10 publications with GDF-15 and SP1
HIF1A active protein	>8 publications with GDF-15 and HIF1A
FOS active protein	>8 publications with GDF-15 and FOS
AKT1 active protein	>6 publications with GDF-15 and AKT1
IL6 active protein	>5 publications with GDF-15 and IL6
MAPK8 active protein	>1 publications with GDF-15 and MAPK8

Diseases associated with GDF-15 active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>178 publications with GDF-15 and Cardiovascular Diseases
Heart Diseases Antibodies	>134 publications with GDF-15 and Heart Diseases
Inflammation Antibodies	>97 publications with GDF-15 and Inflammation
Heart Failure Antibodies	>68 publications with GDF-15 and Heart Failure
Gastrointestinal Neoplasms Antibodies	>65 publications with GDF-15 and Gastrointestinal Neoplasms
Anemia Antibodies	>60 publications with GDF-15 and Anemia
Myocardial Ischemia Antibodies	>58 publications with GDF-15 and Myocardial Ischemia
Prostatic Neoplasms Antibodies	>51 publications with GDF-15 and Prostatic Neoplasms
Necrosis Antibodies	>44 publications with GDF-15 and Necrosis
Brain Diseases Antibodies	>41 publications with GDF-15 and Brain Diseases

Organs/Tissues associated with GDF-15 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>310 publications with GDF-15 and Blood
Heart Antibodies	>135 publications with GDF-15 and Heart
Brain Antibodies	>88 publications with GDF-15 and Brain
Bone Antibodies	>84 publications with GDF-15 and Bone
Prostate Antibodies	>75 publications with GDF-15 and Prostate
Vascular Antibodies	>57 publications with GDF-15 and Vascular
Liver Antibodies	>49 publications with GDF-15 and Liver
Lung Antibodies	>44 publications with GDF-15 and Lung
Kidney Antibodies	>35 publications with GDF-15 and Kidney
Muscle Antibodies	>32 publications with GDF-15 and Muscle