Human Recombinant PRDX6 Active Protein – Cat# MBS844292

PRDX 6 (PRDX6) Human Recombinant Active Protein

Name: PRDX6 Active Protein; PRDX 6; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS844292
Price: 485 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844292

Background: Peroxiredoxin 6, also known as PRDX 6, is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell and can reduce H2O2 and short… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PRDX 6 (PRDX6), Active Protein

Full Product Name

Human Recombinant PRDX 6

Product Gene Name

PRDX6 active protein

Product Synonym Names

Peroxiredoxin 6; 1-Cys; aiPLA2; AOP2; NSGPx; p29; PRX.; Human Recombinant PRDX 6

Sequence

MGSSHHHHHH SSGLVPRGSH MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP

Host

E Coli

Form/Format

1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol.
Appearance: Liquid

Purity/Purification

>=95%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

27.1 kDa

OMIM

602316

3D Structure

ModBase 3D Structure for P30041

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity: approximately 95-120 pmole/min/ug.

Unit Definition

Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25 degree C for 1 minute.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for PRDX6 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for PRDX6 active protein

SDS-PAGE

Other Notes

Small volumes of PRDX6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX6 purchase

MBS844292 is an active protein targeting PRDX6. Also known as Human Recombinant PRDX 6. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX6. It may not necessarily be applicable to this product.

NCBI GI #

4758638

NCBI GeneID

9588

NCBI Accession #

NP_004896.1

UniProt Primary Accession #

P30041

UniProt Secondary Accession #

P32077; Q5TAH4; Q5ZEZ8; A8JZY7

UniProt Related Accession #

P30041

GenBank Nucleotide #

NM_004905.2

NCBI Official Full Name

peroxiredoxin-6

NCBI Official Synonym Full Names

peroxiredoxin 6

NCBI Official Symbol

PRDX6

NCBI Official Synonym Symbols

PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m

UniProt Protein Name

Peroxiredoxin-6

UniProt Synonym Protein Names

1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2 (EC:3.1.1.-); aiPLA2; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase (EC:1.11.1.9); NSGPx; Red blood cells page spot 12

Protein Family

Peroxiredoxin

UniProt Gene Name

PRDX6

UniProt Synonym Gene Names

AOP2; KIAA0106; 1-Cys PRX; aiPLA2; NSGPx

UniProt Entry Name

PRDX6_HUMAN

NCBI Protein Information

peroxiredoxin-6

NCBI Summary for PRDX6

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

UniProt Comments for PRDX6

PRDX6: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Belongs to the AhpC/TSA family. Rehydrin subfamily.

Protein type: Phospholipase; Energy Metabolism - methane; Amino Acid Metabolism - phenylalanine; Oxidoreductase; EC 1.11.1.15; EC 1.11.1.9

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; membrane; lysosome; cytoplasm; cytoplasmic membrane-bound vesicle; cytosol

Molecular Function: antioxidant activity; phospholipase A2 activity; protein binding; peroxiredoxin activity; glutathione peroxidase activity

Biological Process: response to reactive oxygen species; phospholipid catabolic process; hydrogen peroxide catabolic process; response to oxidative stress

Research Articles on PRDX6

1. Several regions of reduced PRDX6 are in a substantially different conformation from that of the crystal structure of the peroxidase catalytic intermediate. The differences between the two structures likely reflect catalysis-related conformational changes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRDX6 active protein

Reference Product	PubMed Publications
PRDX2 active protein	>17 publications with PRDX6 and PRDX2
SOD1 active protein	>8 publications with PRDX6 and SOD1
PRX active protein	>6 publications with PRDX6 and PRX
GSTP1 active protein	>6 publications with PRDX6 and GSTP1
GPX4 active protein	>1 publications with PRDX6 and GPX4
NIT2 active protein	>1 publications with PRDX6 and NIT2

Diseases associated with PRDX6 active protein

Disease Name	Pubmed Publications
Death Antibodies	>26 publications with PRDX6 and Death
Nervous System Diseases Antibodies	>19 publications with PRDX6 and Nervous System Diseases
Lung Diseases Antibodies	>18 publications with PRDX6 and Lung Diseases
Disease Models, Animal Antibodies	>18 publications with PRDX6 and Disease Models, Animal
Inflammation Antibodies	>17 publications with PRDX6 and Inflammation
Necrosis Antibodies	>10 publications with PRDX6 and Necrosis
Cardiovascular Diseases Antibodies	>10 publications with PRDX6 and Cardiovascular Diseases
Atherosclerosis Antibodies	>8 publications with PRDX6 and Atherosclerosis
Liver Diseases Antibodies	>8 publications with PRDX6 and Liver Diseases
Lung Neoplasms Antibodies	>8 publications with PRDX6 and Lung Neoplasms

Organs/Tissues associated with PRDX6 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>51 publications with PRDX6 and Lung
Blood Antibodies	>33 publications with PRDX6 and Blood
Brain Antibodies	>32 publications with PRDX6 and Brain
Liver Antibodies	>29 publications with PRDX6 and Liver
Eye Antibodies	>16 publications with PRDX6 and Eye
Vascular Antibodies	>16 publications with PRDX6 and Vascular
Muscle Antibodies	>11 publications with PRDX6 and Muscle
Kidney Antibodies	>11 publications with PRDX6 and Kidney
Nerve Antibodies	>9 publications with PRDX6 and Nerve
Skin Antibodies	>7 publications with PRDX6 and Skin