CADM1 Human Cellexp Active Protein

CADM1: a single-pass type I membrane protein that ediates homophilic cell-cell adhesion, and heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Tumor suppressor; Cell adhesion; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: synaptic vesicle; axon; basolateral plasma membrane; dendrite; plasma membrane; integral to membrane; intercellular junction

Molecular Function: protein binding; protein homodimerization activity; cell adhesion molecule binding; PDZ domain binding; receptor binding

Biological Process: unidimensional cell growth; intercellular junction assembly and maintenance; apoptosis; activated T cell proliferation; cell recognition; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity; liver development; calcium-independent cell-cell adhesion; heterophilic cell adhesion; synaptogenesis; detection of stimulus; spermatogenesis; brain development; cell differentiation; homophilic cell adhesion; positive regulation of cytokine secretion; T cell mediated cytotoxicity