BMP-11/GDF-11 (GDF11) Active Protein

Name: GDF11 Active Protein; BMP-11/GDF-11; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844315
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844315

Background: GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell cycle in the G1 phase.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BMP-11/GDF-11 (GDF11), Active Protein

Full Product Name

BMP-11 / GDF-11, human recombinant

Product Gene Name

GDF11 active protein

Product Synonym Names

Growth/Differentiation Factor-11; BMP-11

Sequence

NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

25 kDa

OMIM

603936

3D Structure

ModBase 3D Structure for O95390

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.08-0.10 mug/ml.

Biological Activity

Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.08-0.10 mug/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for GDF11 active protein

Cytokines; Growth Factors & Hormones; BMPsCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; BMPs Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growt

Applications Tested/Suitable for GDF11 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of GDF11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF11 purchase

MBS844315 is an active protein targeting GDF11. Also known as BMP-11 / GDF-11, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF11. It may not necessarily be applicable to this product.

NCBI GI #

5031613

NCBI GeneID

10220

NCBI Accession #

NP_005802.1

UniProt Primary Accession #

O95390

UniProt Secondary Accession #

Q9UID1; Q9UID2

UniProt Related Accession #

O95390

GenBank Nucleotide #

NM_005811.3

NCBI Official Full Name

growth/differentiation factor 11

NCBI Official Synonym Full Names

growth differentiation factor 11

NCBI Official Symbol

GDF11

NCBI Official Synonym Symbols

BMP11; BMP-11

UniProt Protein Name

Growth/differentiation factor 11

UniProt Synonym Protein Names

Bone morphogenetic protein 11; BMP-11

Protein Family

Growth/differentiation factor

UniProt Gene Name

GDF11

UniProt Synonym Gene Names

BMP11; GDF-11; BMP-11

UniProt Entry Name

GDF11_HUMAN

NCBI Protein Information

growth/differentiation factor 11

NCBI Summary for GDF11

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

UniProt Comments for GDF11

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; skeletal development; metanephros development; cell development; growth

Research Articles on GDF11

1. Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF11 active protein

Reference Product	PubMed Publications
WFIKKN2 active protein	>4 publications with GDF11 and WFIKKN2
ACVR2B active protein	>3 publications with GDF11 and ACVR2B
ACVR1C active protein	>2 publications with GDF11 and ACVR1C
ACVR1B active protein	>2 publications with GDF11 and ACVR1B
MAFA active protein	>1 publications with GDF11 and MAFA
FOXG1 active protein	>1 publications with GDF11 and FOXG1
PAX6 active protein	>1 publications with GDF11 and PAX6
ATOH7 active protein	>1 publications with GDF11 and ATOH7

Diseases associated with GDF11 active protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>6 publications with GDF11 and Disease Models, Animal
Atrophy Antibodies	>4 publications with GDF11 and Atrophy
Kidney Diseases Antibodies	>3 publications with GDF11 and Kidney Diseases
Brain Diseases Antibodies	>2 publications with GDF11 and Brain Diseases
Anemia, Hemolytic Antibodies	>2 publications with GDF11 and Anemia, Hemolytic
Urogenital Abnormalities Antibodies	>1 publications with GDF11 and Urogenital Abnormalities
Hyperplasia Antibodies	>1 publications with GDF11 and Hyperplasia
Fatty Liver Antibodies	>1 publications with GDF11 and Fatty Liver
Pain Antibodies	>1 publications with GDF11 and Pain
Inflammation Antibodies	>1 publications with GDF11 and Inflammation

Organs/Tissues associated with GDF11 active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>81 publications with GDF11 and Bone
Muscle Antibodies	>37 publications with GDF11 and Muscle
Blood Antibodies	>21 publications with GDF11 and Blood
Embryonic Tissue Antibodies	>16 publications with GDF11 and Embryonic Tissue
Heart Antibodies	>11 publications with GDF11 and Heart
Nerve Antibodies	>11 publications with GDF11 and Nerve
Brain Antibodies	>10 publications with GDF11 and Brain
Kidney Antibodies	>9 publications with GDF11 and Kidney
Liver Antibodies	>6 publications with GDF11 and Liver
Eye Antibodies	>6 publications with GDF11 and Eye