Oncostatin M (OSM) Active Protein

Name: OSM Active Protein; Oncostatin M; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844346
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844346

Background: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Oncostatin M (Osm), Active Protein

Full Product Name

Oncostatin M, rat recombinant

Product Gene Name

Osm active protein

Product Synonym Names

OSM

Sequence

MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

24.4 kDa

3D Structure

ModBase 3D Structure for Q65Z15

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Assay #1: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 mug/ml.Assay #2: Determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells.

Biological Activity

Assay #1: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 mug/ml. Assay #2: Determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for Osm active protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and E

Applications Tested/Suitable for Osm active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of Osm active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Osm purchase

MBS844346 is an active protein targeting Osm. Also known as Oncostatin M, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Osm. It may not necessarily be applicable to this product.

NCBI GI #

55741439

NCBI GeneID

289747

NCBI Accession #

NP_001006962.1

UniProt Primary Accession #

Q65Z15

UniProt Related Accession #

Q65Z15

GenBank Nucleotide #

NM_001006961.1

NCBI Official Full Name

oncostatin-M

NCBI Official Synonym Full Names

oncostatin M

NCBI Official Symbol

Osm

UniProt Protein Name

Oncostatin-M

Protein Family

Oncostatin

UniProt Gene Name

Osm

UniProt Synonym Gene Names

OSM

UniProt Entry Name

ONCM_RAT

NCBI Protein Information

oncostatin-M

NCBI Summary for Osm

mouse homolog is a cytokine and an immediate early gene [RGD, Feb 2006]

UniProt Comments for Osm

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Research Articles on Osm

1. Results indicate that osteosarcoma cells stably producing OSM do not develop resistance to this cytokine and thus could be a valuable new tool to study the anti-cancer effect of OSM in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Osm active protein

Reference Product	PubMed Publications
Lifr active protein	>396 publications with Osm and Lifr
Cntf active protein	>185 publications with Osm and Cntf
Osmr active protein	>72 publications with Osm and Osmr
Jak2 active protein	>48 publications with Osm and Jak2
Il6 active protein	>28 publications with Osm and Il6
Jak3 active protein	>17 publications with Osm and Jak3
Csf3 active protein	>2 publications with Osm and Csf3
Epor active protein	>1 publications with Osm and Epor
Ctf1 active protein	>1 publications with Osm and Ctf1

Diseases associated with Osm active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>219 publications with Osm and Inflammation
Necrosis Antibodies	>156 publications with Osm and Necrosis
Vascular Diseases Antibodies	>79 publications with Osm and Vascular Diseases
Disease Models, Animal Antibodies	>71 publications with Osm and Disease Models, Animal
Kidney Diseases Antibodies	>54 publications with Osm and Kidney Diseases
Fibrosis Antibodies	>50 publications with Osm and Fibrosis
Breast Neoplasms Antibodies	>45 publications with Osm and Breast Neoplasms
Liver Neoplasms Antibodies	>44 publications with Osm and Liver Neoplasms
Lung Diseases Antibodies	>40 publications with Osm and Lung Diseases
Neoplasms, Experimental Antibodies	>31 publications with Osm and Neoplasms, Experimental

Organs/Tissues associated with Osm active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>195 publications with Osm and Liver