Tl-1a (TNFSF15) Active Protein

Name: TNFSF15 Active Protein; Tl-1a; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844362
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844362

Background: TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TL-1A (TNFSF15), Active Protein

Full Product Name

TL-1A, human recombinant

Product Gene Name

TNFSF15 active protein

Product Synonym Names

TNFSF15; VEGI

Sequence

QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Tris, pH 8.5, and 75 mM Arginine.
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

22.0 kDa

OMIM

604052

3D Structure

ModBase 3D Structure for O95150

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by its ability to stimulate IFN-gamma production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Note: Results may vary with PBMC donors.

Biological Activity

Determined by its ability to stimulate IFN-gamma production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Note: Results may vary with PBMC donors.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TNFSF15 active protein

Cytokines; Growth Factors & Hormones; TNFsCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; TNFsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth

Applications Tested/Suitable for TNFSF15 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of TNFSF15 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFSF15 purchase

MBS844362 is an active protein targeting TNFSF15. Also known as TL-1A, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFSF15. It may not necessarily be applicable to this product.

NCBI GI #

324072728

NCBI GeneID

9966

NCBI Accession #

NP_001191273.1

UniProt Primary Accession #

O95150

UniProt Secondary Accession #

Q3SX69; Q5VJK8; Q5VWH1; Q8NFE9

UniProt Related Accession #

O95150

GenBank Nucleotide #

NM_001204344.1

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 15 isoform VEGI-192

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 15

NCBI Official Symbol

TNFSF15

NCBI Official Synonym Symbols

TL1; TL1A; VEGI; VEGI192A

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 15

UniProt Synonym Protein Names

TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF15

UniProt Synonym Gene Names

TL1; VEGI

UniProt Entry Name

TNF15_HUMAN

NCBI Protein Information

tumor necrosis factor ligand superfamily member 15

NCBI Summary for TNFSF15

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

UniProt Comments for TNFSF15

TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; cytokine metabolic process; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion

Research Articles on TNFSF15

1. Soluble TL1A synergized with IL-23 to stimulate peripheral blood mononuclear cells from patients with psoriasis vulgaris to produce IL-17.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFSF15 active protein

Reference Product	PubMed Publications
TNFRSF25 active protein	>41 publications with TNFSF15 and TNFRSF25
TNFRSF6B active protein	>15 publications with TNFSF15 and TNFRSF6B
IL13 active protein	>5 publications with TNFSF15 and IL13
IFNG active protein	>2 publications with TNFSF15 and IFNG
TNFSF4 active protein	>2 publications with TNFSF15 and TNFSF4
TNFRSF1A active protein	>1 publications with TNFSF15 and TNFRSF1A

Diseases associated with TNFSF15 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>186 publications with TNFSF15 and Necrosis
Inflammation Antibodies	>53 publications with TNFSF15 and Inflammation
Colitis, Ulcerative Antibodies	>31 publications with TNFSF15 and Colitis, Ulcerative
Disease Models, Animal Antibodies	>14 publications with TNFSF15 and Disease Models, Animal
Enteritis Antibodies	>9 publications with TNFSF15 and Enteritis
Fibrosis Antibodies	>7 publications with TNFSF15 and Fibrosis
Atherosclerosis Antibodies	>6 publications with TNFSF15 and Atherosclerosis
Lung Diseases Antibodies	>5 publications with TNFSF15 and Lung Diseases
Cardiovascular Diseases Antibodies	>5 publications with TNFSF15 and Cardiovascular Diseases
Diarrhea Antibodies	>4 publications with TNFSF15 and Diarrhea

Organs/Tissues associated with TNFSF15 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>99 publications with TNFSF15 and Blood
Intestine Antibodies	>28 publications with TNFSF15 and Intestine
Embryonic Tissue Antibodies	>10 publications with TNFSF15 and Embryonic Tissue
Kidney Antibodies	>9 publications with TNFSF15 and Kidney
Lung Antibodies	>8 publications with TNFSF15 and Lung
Eye Antibodies	>5 publications with TNFSF15 and Eye
Brain Antibodies	>4 publications with TNFSF15 and Brain
Thyroid Antibodies	>2 publications with TNFSF15 and Thyroid
Prostate Antibodies	>1 publications with TNFSF15 and Prostate
Testis Antibodies	>1 publications with TNFSF15 and Testis