• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GRO-Beta/MIP-2 (GROB) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844370

Background: Rat GRO-beta/MIP-2 promotes neutrophil chemotaxis and degranulation. Recombinant rat GRO-beta is a 7.9 kDa protein containing 73 amino acid residues. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
GRO-beta/MIP-2 (GROB), Active Protein
Full Product Name
GRO-beta / MIP-2, rat recombinant
Product Gene Name
GROB active protein
Product Synonym Names
Growth Regulated Protein/Melanoma Growth Stimulatory Activity; GRO alpha; MGSA alpha; CXCL1; NAP-3; GRO1; KC (murine) CINC (rat); Neutrophil-activating protein 3
Host
E Coli
Form/Format
Lyophilized with no additives.
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
7.9 kDa
3D Structure
ModBase 3D Structure for P30348
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by its ability to chemoattract rat neutrophils using a concentration range of 10-100 ng/ml.
Results
10-100 ng/ml.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for GROB active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for GROB active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of GROB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GROB purchase

MBS844370 is an active protein targeting GROB. Also known as GRO-beta / MIP-2, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GROB. It may not necessarily be applicable to this product.

NCBI GI #
16758460
NCBI GeneID
114105
NCBI Accession #
NP_446099.1
UniProt Primary Accession #
P30348
UniProt Secondary Accession #
Q5WA60
UniProt Related Accession #
P30348
GenBank Nucleotide #
NM_053647.1
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
Cxcl2
NCBI Official Synonym Symbols
Mip-2; Scyb2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2
UniProt Gene Name
Cxcl2
UniProt Synonym Gene Names
Cinc3; Mip-2; Mip2; Scyb2; CINC-3; MIP2
UniProt Entry Name
CXCL2_RAT
NCBI Protein Information
C-X-C motif chemokine 2

NCBI Summary for GROB

chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]

UniProt Comments for GROB

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; wound healing; leukocyte chemotaxis; response to amphetamine; response to glucocorticoid stimulus; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; response to molecule of bacterial origin; response to gamma radiation; immune response; inflammatory response
Show more

Research Articles on GROB

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GROB active protein

 Reference Product  PubMed Publications
 Cxcr2 active protein  >161 publications with GROB and Cxcr2
 Cxcl10 active protein  >116 publications with GROB and Cxcl10
 Cxcl5 active protein  >105 publications with GROB and Cxcl5
 Ccl20 active protein  >81 publications with GROB and Ccl20
 Cxcl12 active protein  >54 publications with GROB and Cxcl12
 Ccr1 active protein  >27 publications with GROB and Ccr1
 Cxcr1 active protein  >27 publications with GROB and Cxcr1
 Cxcl11 active protein  >23 publications with GROB and Cxcl11
 Cxcr3 active protein  >18 publications with GROB and Cxcr3

Diseases associated with GROB active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1076 publications with GROB and Inflammation
 Necrosis Antibodies  >674 publications with GROB and Necrosis
 Lung Diseases Antibodies  >410 publications with GROB and Lung Diseases
 Disease Models, Animal Antibodies  >382 publications with GROB and Disease Models, Animal
 Lung Injury Antibodies  >277 publications with GROB and Lung Injury
 Pneumonia Antibodies  >178 publications with GROB and Pneumonia
 Reperfusion Injury Antibodies  >117 publications with GROB and Reperfusion Injury
 Edema Antibodies  >102 publications with GROB and Edema
 Wounds and Injuries Antibodies  >100 publications with GROB and Wounds and Injuries
 Skin Diseases Antibodies  >88 publications with GROB and Skin Diseases

Organs/Tissues associated with GROB active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >663 publications with GROB and Lung
 Connective Tissue Antibodies  >29 publications with GROB and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000