IFN-Omega (IFNE1) Active Protein

Name: IFNE1 Active Protein; IFN-Omega; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844383
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844383

Background: IFN-omega is a type I interferon, which can be induced by virus-infected leukocytes. Members of the type I interferon family, which includes IFN-alpha, IFN-beta, and IFN-omega, signal through IFNAR-1/IFNAR-2 receptor complex, and exert antiviral… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IFN-omega (IFNE1), Active Protein

Full Product Name

IFN-omega, human recombinant

Product Gene Name

IFNE1 active protein

Product Synonym Names

IFN alpha II-1; IFNW1

Sequence

CDLPQNHGLL SRNTLVLLHQ MRRISPFLCL KDRRDFRFPQ EMVKGSQLQK AHVMSVLHEM LQQIFSLFHT ERSSAAWNMT LLDQLHTGLH QQLQHLETCL LQVVGEGESA GAISSPALTL RRYFQGIRVY LKEKKYSDCA WEVVRMEIMK SLFLSTNMQE RLRSKDRDLG SS

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

19.9 kDa

OMIM

615223

3D Structure

ModBase 3D Structure for Q86WN2

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is <= 0.01 ng/ml, corresponding to a specific activity of >= 1 x 10^8 units/mg.

Biological Activity

The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is <= 0.01 ng/ml, corresponding to a specific activity of >= 1 x 10^8 units/mg.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for IFNE1 active protein

Proteins and Enzymes; Cytokines; Growth Factors & Hormones; IFNsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF)

Applications Tested/Suitable for IFNE1 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IFNE1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNE1 purchase

MBS844383 is an active protein targeting IFNE1. Also known as IFN-omega, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNE1. It may not necessarily be applicable to this product.

NCBI GI #

28882045

NCBI GeneID

338376

NCBI Accession #

NP_795372.1

UniProt Primary Accession #

Q86WN2

UniProt Related Accession #

Q86WN2

GenBank Nucleotide #

NM_176891.4

NCBI Official Full Name

interferon epsilon

NCBI Official Synonym Full Names

interferon, epsilon

NCBI Official Symbol

IFNE

NCBI Official Synonym Symbols

IFN-E; IFNE1; IFNT1; INFE1; PRO655

UniProt Protein Name

Interferon epsilon

UniProt Synonym Protein Names

Interferon epsilon-1

Protein Family

Interferon

UniProt Gene Name

IFNE

UniProt Synonym Gene Names

IFNE1; IFN-epsilon

UniProt Entry Name

IFNE_HUMAN

NCBI Protein Information

interferon epsilon

UniProt Comments for IFNE1

IFNE1: Belongs to the alpha/beta interferon family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p21.3

Cellular Component: extracellular space

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; response to exogenous dsRNA; B cell differentiation; cytokine and chemokine mediated signaling pathway; defense response to bacterium; regulation of MHC class I biosynthetic process; natural killer cell activation during immune response; innate immune response; defense response to virus; humoral immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein; T cell activation during immune response

Research Articles on IFNE1

1. T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-epsilon is a risk factor for the development of intracerebral hemorrhage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IFNE1 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
RIG-I-like Receptor Signaling Pathway antibodies	RIG-I-like Receptor Signaling Pathway Diagram
RIG-I-like Receptor Signaling Pathway antibodies	RIG-I-like Receptor Signaling Pathway Diagram

Diseases associated with IFNE1 active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1 publications with IFNE1 and Cardiovascular Diseases
Inflammation Antibodies	>1 publications with IFNE1 and Inflammation