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PLGF-2 (PGF) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844394

Background: PLGF-2 is produced in E. coli as a homodimer containing 2 x 153 amino acids and having a total molecular mass of 36 kDa. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PLGF-2 (PGF), Active Protein
Full Product Name
PLGF-2, human recombinant
Product Gene Name
PGF active protein
Product Synonym Names
Placenta Growth Factor-2; PGFL
Host
E Coli
Form/Format
Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein
Purity/Purification
>=90%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
18.0 kDa
OMIM
601121
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 mug/mul. The solution can then be diluted into other aqueous buffer
Endotoxin Level
<0.1 ng/mug
Biological Activity
The PLFG-2 is fully biologically active when compared with standards. Recombinant human PIGF-2 can bind to immobilized rh-sFlt-1 (100 ng/well) with linear range at 0.3-10 ng/ml.
Results
0.3-10 ng/ml
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for PGF active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of PGF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGF purchase

MBS844394 is an active protein targeting PGF. Also known as PLGF-2, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PGF. It may not necessarily be applicable to this product.

NCBI GI #
7717236
NCBI GeneID
5228
NCBI Accession #
AAB30462
UniProt Secondary Accession #
Q07101; Q9BV78; Q9Y6S8
UniProt Related Accession #
P49763
NCBI Official Full Name
placenta growth factor 2
NCBI Official Synonym Full Names
placental growth factor
NCBI Official Symbol
PGF
NCBI Official Synonym Symbols
PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760
UniProt Protein Name
Placenta growth factor
Protein Family
Placenta growth factor
UniProt Gene Name
PGF
UniProt Synonym Gene Names
PGFL; PLGF; PlGF
UniProt Entry Name
PLGF_HUMAN
NCBI Protein Information
placenta growth factor

NCBI Summary for PGF

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

UniProt Comments for PGF

PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation
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Research Articles on PGF

1. Maternal PGF concentrations were lower in twin than singleton pregnancies at week 35 only Placental weight appeared to be inversely correlated with maternal sFlt-1/PGF ratio at the end of pregnancy in both twins and singletons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGF active protein

 Reference Product  PubMed Publications
 VEGFA active protein  >26 publications with PGF and VEGFA
 FLT1 active protein  >21 publications with PGF and FLT1
 KDR active protein  >14 publications with PGF and KDR
 VEGFC active protein  >8 publications with PGF and VEGFC
 VEGFB active protein  >5 publications with PGF and VEGFB
 NRP1 active protein  >5 publications with PGF and NRP1
 TEK active protein  >4 publications with PGF and TEK
 FIGF active protein  >3 publications with PGF and FIGF
 FLT4 active protein  >3 publications with PGF and FLT4
 PIK3CA active protein  >1 publications with PGF and PIK3CA

Pathways associated with PGF active protein

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with PGF active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >395 publications with PGF and Cardiovascular Diseases
 Inflammation Antibodies  >296 publications with PGF and Inflammation
 Hypertension Antibodies  >198 publications with PGF and Hypertension
 Disease Models, Animal Antibodies  >162 publications with PGF and Disease Models, Animal
 Necrosis Antibodies  >159 publications with PGF and Necrosis
 Heart Diseases Antibodies  >132 publications with PGF and Heart Diseases
 Lung Diseases Antibodies  >131 publications with PGF and Lung Diseases
 Atherosclerosis Antibodies  >93 publications with PGF and Atherosclerosis
 Brain Diseases Antibodies  >73 publications with PGF and Brain Diseases
 Kidney Diseases Antibodies  >71 publications with PGF and Kidney Diseases

Organs/Tissues associated with PGF active protein

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >774 publications with PGF and Ovary
 Uterus Antibodies  >733 publications with PGF and Uterus
 Muscle Antibodies  >508 publications with PGF and Muscle
 Heart Antibodies  >253 publications with PGF and Heart
 Lung Antibodies  >241 publications with PGF and Lung
 Kidney Antibodies  >215 publications with PGF and Kidney
 Placenta Antibodies  >215 publications with PGF and Placenta
 Embryonic Tissue Antibodies  >200 publications with PGF and Embryonic Tissue
 Brain Antibodies  >196 publications with PGF and Brain
 Liver Antibodies  >139 publications with PGF and Liver
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