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Ip-10 (IP10) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844433

Background: Human IP-10 is an 8.5 kDa protein produced by several cell types during the delayed type hypersensitivity response. IP-10 acts as a chemoattractant towards monocytes, lymphocytes, and certain T cells. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IP-10 (IP10), Active Protein
Full Product Name
IP-10, human recombinant
Product Gene Name
IP10 active protein
Product Synonym Names
Small inducible cytokine B10; CXCL10; 10 kDa interferon-gamma-induced protein; gamma-IP10; IP-10; chemokine (C-X-C motif) ligand 10; C7; IFI10; INP10; crg-2; mob-1; SCYB10; gIP-10.
Host
E Coli
Form/Format
Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
8.5 kDa
OMIM
147310
3D Structure
ModBase 3D Structure for P02778
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1 ug/ul. The solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
The biological activity of human IP-10 was determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 10-50 ng/ml.
Results
10-50 ng/ml.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for IP10 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for IP10 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of IP10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP10 purchase

MBS844433 is an active protein targeting IP10. Also known as IP-10, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IP10. It may not necessarily be applicable to this product.

NCBI GI #
149999382
NCBI GeneID
3627
NCBI Accession #
NP_001556.2
UniProt Primary Accession #
P02778
UniProt Secondary Accession #
Q96QJ5
UniProt Related Accession #
P02778
GenBank Nucleotide #
NM_001565.3
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
CXCL10
NCBI Official Synonym Symbols
C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10
UniProt Gene Name
CXCL10
UniProt Synonym Gene Names
INP10; SCYB10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_HUMAN
NCBI Protein Information
C-X-C motif chemokine 10

NCBI Summary for IP10

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
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UniProt Comments for IP10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of release of sequestered calcium ion into cytosol; response to cold; regulation of protein kinase activity; negative regulation of myoblast differentiation; inflammatory response; defense response to virus
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Research Articles on IP10

1. Serum biomarkers OPN, IP-10, and neutrophil counts are useful in detecting Mycobacterium tuberculosis infection and may have utility in monitoring the course of the disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IP10 active protein

 Reference Product  PubMed Publications
 CXCR3 active protein  >858 publications with IP10 and CXCR3
 CCL5 active protein  >665 publications with IP10 and CCL5
 CXCL1 active protein  >223 publications with IP10 and CXCL1
 CCR5 active protein  >177 publications with IP10 and CCR5
 CCL20 active protein  >110 publications with IP10 and CCL20
 CCL11 active protein  >104 publications with IP10 and CCL11
 IL8 active protein  >86 publications with IP10 and IL8
 CCR3 active protein  >48 publications with IP10 and CCR3
 PF4 active protein  >13 publications with IP10 and PF4

Pathways associated with IP10 active protein

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with IP10 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1224 publications with IP10 and Inflammation
 Necrosis Antibodies  >688 publications with IP10 and Necrosis
 Disease Models, Animal Antibodies  >355 publications with IP10 and Disease Models, Animal
 Lung Diseases Antibodies  >347 publications with IP10 and Lung Diseases
 Liver Diseases Antibodies  >244 publications with IP10 and Liver Diseases
 Brain Diseases Antibodies  >212 publications with IP10 and Brain Diseases
 Cardiovascular Diseases Antibodies  >180 publications with IP10 and Cardiovascular Diseases
 Fibrosis Antibodies  >131 publications with IP10 and Fibrosis
 Neoplasms, Experimental Antibodies  >122 publications with IP10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >91 publications with IP10 and Kidney Diseases

Organs/Tissues associated with IP10 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2117 publications with IP10 and Blood
 Lung Antibodies  >461 publications with IP10 and Lung
 Liver Antibodies  >283 publications with IP10 and Liver
 Kidney Antibodies  >187 publications with IP10 and Kidney
 Lymph Node Antibodies  >164 publications with IP10 and Lymph Node
 Muscle Antibodies  >125 publications with IP10 and Muscle
 Intestine Antibodies  >94 publications with IP10 and Intestine
 Nerve Antibodies  >62 publications with IP10 and Nerve
 Uterus Antibodies  >35 publications with IP10 and Uterus
 Placenta Antibodies  >28 publications with IP10 and Placenta
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