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GRO-Beta (GROB) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844456

Background: Human GRO-beta is a member of the C-X-C family of chemokines and promotes neutrophil and basophil chemotaxis and degranulation. GRO-beta like GRO-alpha specifically inhibits growth factor-stimulated proliferation of capillary endothelial cells in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GRO-beta (GROB), Active Protein
Full Product Name
GRO-beta, human recombinant
Product Gene Name
GROB active protein
Product Synonym Names
Growth Regulated Protein/Melanoma Growth Stimulatory Activity; GRO alpha; MGSA alpha; CXCL1; NAP-3; GRO1; KC (murine) CINC (rat); Neutrophil-activating protein 3; Growth Regulated Protein/Melanoma Growth Stimulatory Activity (MGSA beta); CXCL2; MIP-2; GRO2
Host
E Coli
Form/Format
Lyophilized with no additives.
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
7.9 kDa
OMIM
139110
3D Structure
ModBase 3D Structure for P19875
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by its ability to chemoattract CXCR2 transfected 293 cells using a concentration range of 10-100 ng/ml.
Results
10-100 ng/ml.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for GROB active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for GROB active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of GROB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GROB purchase

MBS844456 is an active protein targeting GROB. Also known as GRO-beta, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GROB. It may not necessarily be applicable to this product.

NCBI GI #
4504155
NCBI GeneID
2920
NCBI Accession #
NP_002080.1
UniProt Primary Accession #
P19875
UniProt Secondary Accession #
Q6FGD6; Q9UPB8
UniProt Related Accession #
P19875
GenBank Nucleotide #
NM_002089.3
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
CXCL2
NCBI Official Synonym Symbols
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Growth-regulated protein beta; Gro-beta
Protein Family
Growth-regulated protein
UniProt Gene Name
CXCL2
UniProt Synonym Gene Names
GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF
UniProt Entry Name
CXCL2_HUMAN
NCBI Protein Information
C-X-C motif chemokine 2

NCBI Summary for GROB

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
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UniProt Comments for GROB

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; chemotaxis; inflammatory response; regulation of cell proliferation
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Research Articles on GROB

1. The results link CXCL1 and CXCL2 chemokines with bone marrow adiposity and implicate CXCR2 signaling in promoting effects of marrow fat on progression of skeletal tumors in bone.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GROB active protein

 Reference Product  PubMed Publications
 CXCR2 active protein  >161 publications with GROB and CXCR2
 CCL5 active protein  >133 publications with GROB and CCL5
 CXCL10 active protein  >116 publications with GROB and CXCL10
 CCL20 active protein  >81 publications with GROB and CCL20
 CXCL12 active protein  >54 publications with GROB and CXCL12
 CCR2 active protein  >44 publications with GROB and CCR2
 CXCR1 active protein  >27 publications with GROB and CXCR1
 CXCL11 active protein  >23 publications with GROB and CXCL11
 CCL19 active protein  >7 publications with GROB and CCL19
 CXCL16 active protein  >5 publications with GROB and CXCL16

Pathways associated with GROB active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with GROB active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1076 publications with GROB and Inflammation
 Necrosis Antibodies  >674 publications with GROB and Necrosis
 Lung Diseases Antibodies  >410 publications with GROB and Lung Diseases
 Disease Models, Animal Antibodies  >382 publications with GROB and Disease Models, Animal
 Lung Injury Antibodies  >277 publications with GROB and Lung Injury
 Pneumonia Antibodies  >178 publications with GROB and Pneumonia
 Reperfusion Injury Antibodies  >117 publications with GROB and Reperfusion Injury
 Edema Antibodies  >102 publications with GROB and Edema
 Wounds and Injuries Antibodies  >100 publications with GROB and Wounds and Injuries
 Skin Diseases Antibodies  >88 publications with GROB and Skin Diseases

Organs/Tissues associated with GROB active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1114 publications with GROB and Blood
 Lung Antibodies  >663 publications with GROB and Lung
 Liver Antibodies  >216 publications with GROB and Liver
 Bone Antibodies  >177 publications with GROB and Bone
 Bone Marrow Antibodies  >146 publications with GROB and Bone Marrow
 Brain Antibodies  >130 publications with GROB and Brain
 Intestine Antibodies  >125 publications with GROB and Intestine
 Kidney Antibodies  >100 publications with GROB and Kidney
 Eye Antibodies  >57 publications with GROB and Eye
 Pancreas Antibodies  >47 publications with GROB and Pancreas
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