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Il-33 (IL33) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844479

Background: Recombinant mouse IL-33 produced from E. coli is a single, non-glycosylated, polypeptide chain consisting of 158 amino acids and having a total molecular mass of 17.5 kDa. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL-33 (IL33), Active Protein
Full Product Name
IL-33, murine recombinant
Product Gene Name
IL33 active protein
Product Synonym Names
Interleukin 33; DVS27; NF-HEV; NKHEV; C9orf26; Interleukin-1 family member 11; IL- 1F11; Nuclear factor from high endothelial venules; NFEHEV; DKFZp586H0523; RP11-575C20.2; IL-33.
Host
E Coli
Form/Format
Sterile filtered and lyophilized from 20 mM phosphate buffer, pH 7.4, 150 mM NaCl, 1 mM EDTA and 2 mM 2-ME.
Appearance: Lyophilized protein
Purity/Purification
>=97%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
17.5 kDa
3D Structure
ModBase 3D Structure for Q8BVZ5
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers
Endotoxin Level
<0.1 ng/mug
Biological Activity
The ED?? as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is 0.5 ng/ml, corresponding to a specific activity of 2 x 10 units/mg.
Results
0.5 ng/ml
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for IL33 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of IL33 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL33 purchase

MBS844479 is an active protein targeting IL33. Also known as IL-33, murine recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL33. It may not necessarily be applicable to this product.

NCBI GI #
257900495
NCBI GeneID
77125
NCBI Accession #
NP_001158196.1
UniProt Primary Accession #
Q8BVZ5
UniProt Secondary Accession #
Q2YEJ4; Q3TQN0; Q99L46
UniProt Related Accession #
Q8BVZ5
GenBank Nucleotide #
NM_001164724.1
NCBI Official Full Name
interleukin-33
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
Il33
NCBI Official Synonym Symbols
Il-33; Il1f11; NF-HEV; 9230117N10Rik
UniProt Protein Name
Interleukin-33
Protein Family
Interleukin
UniProt Gene Name
Il33
UniProt Synonym Gene Names
IL-33
UniProt Entry Name
IL33_MOUSE
NCBI Protein Information
interleukin-33

UniProt Comments for IL33

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Cellular Component: extracellular space; extracellular region; cytoplasmic vesicle; chromosome; nucleus

Molecular Function: cytokine activity

Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; defense response to virus; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
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Research Articles on IL33

1. IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL33 active protein

 Reference Product  PubMed Publications
 Il1rl1 active protein  >181 publications with IL33 and Il1rl1
 Il6 active protein  >15 publications with IL33 and Il6
 Kit active protein  >6 publications with IL33 and Kit
 Vegfa active protein  >3 publications with IL33 and Vegfa
 Itgam active protein  >2 publications with IL33 and Itgam
 Tff2 active protein  >1 publications with IL33 and Tff2

Diseases associated with IL33 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >208 publications with IL33 and Inflammation
 Asthma Antibodies  >104 publications with IL33 and Asthma
 Hypersensitivity, Immediate Antibodies  >98 publications with IL33 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >98 publications with IL33 and Lung Diseases
 Necrosis Antibodies  >60 publications with IL33 and Necrosis
 Cardiovascular Diseases Antibodies  >57 publications with IL33 and Cardiovascular Diseases
 Heart Diseases Antibodies  >35 publications with IL33 and Heart Diseases
 Fibrosis Antibodies  >25 publications with IL33 and Fibrosis
 Disease Models, Animal Antibodies  >23 publications with IL33 and Disease Models, Animal
 Dermatitis, Atopic Antibodies  >23 publications with IL33 and Dermatitis, Atopic

Organs/Tissues associated with IL33 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >63 publications with IL33 and Lung
 Skin Antibodies  >48 publications with IL33 and Skin
 Bone Antibodies  >26 publications with IL33 and Bone
 Muscle Antibodies  >23 publications with IL33 and Muscle
 Lymph Node Antibodies  >14 publications with IL33 and Lymph Node
 Brain Antibodies  >14 publications with IL33 and Brain
 Connective Tissue Antibodies  >11 publications with IL33 and Connective Tissue
 Eye Antibodies  >9 publications with IL33 and Eye
 Spleen Antibodies  >7 publications with IL33 and Spleen
 Stomach Antibodies  >7 publications with IL33 and Stomach
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