• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Il-13 Alpha 2 Receptor (IL13RA2) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553247

The biological activity of IL-13 is regulated via the IL-13R type I and type II. The type I receptor is a heterodimer of the IL-4R α chain (IL-4Rα) and IL-13Rα1, and ligand-receptor interactions induce phosphorylation of the IL- 4Rα and subsequent… More details

$335 / 0.02 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-13 alpha 2 receptor (IL13RA2), Active Protein
Full Product Name
Human IL-13 alpha 2 receptor Recombinant (IL13RA2)
Product Gene Name
IL13RA2 active protein
Product Synonym Gene Name
IL-13 R
Product Synonym Names
Human IL-13 alpha 2 receptor Recombinant; IL13RA2; IL-13RA2; CD213
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant IL-13 receptor alpha 2 is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant IL13RA2, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
44,176 Da
OMIM
300130
3D Structure
ModBase 3D Structure for Q14627
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Host Note
Optimized DNA sequence encoding extracellular domain of human IL-13 receptor alpha2 including an IgG1 human Fc region was expressed in HEK293 cells.
Biological Activity
Measured by its ability to bind recombinant human Interleukin-13 at a concentration range of 0.3-8ng/ml.
Presentation
Recombinant IL-13 receptor alpha 2 is supplied as lyophilized 0.2 um filtered 50mM Tris, 100mM glycine solution, pH 7.5 and 5% trehalose.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1mg/mL. It is recommended to add 0.1% HSA or BSA for long term storage.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant IL-13RA2 is a homodimer protein consisting of 563 amino acid residue subunits, due to glycosylation migrates as an approximately 130kDa protein on SDS-PAGE.

Product Categories/Family for IL13RA2 active protein

Receptors CD

Other Notes

Small volumes of IL13RA2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL13RA2 purchase

MBS553247 is an active protein targeting IL13RA2. Also known as Human IL-13 alpha 2 receptor Recombinant (IL13RA2). Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL13RA2. It may not necessarily be applicable to this product.

NCBI GI #
10834992
NCBI GeneID
3598
NCBI Accession #
NP_000631.1
UniProt Primary Accession #
Q14627
UniProt Secondary Accession #
O00667; A8K7E2
GenBank Nucleotide #
NM_000640.2
NCBI Official Full Name
interleukin-13 receptor subunit alpha-2
UniProt Protein Name
Interleukin-13 receptor subunit alpha-2
UniProt Synonym Protein Names
Interleukin-13-binding protein
Protein Family
Interleukin-13 receptor
UniProt Gene Name
IL13RA2
UniProt Synonym Gene Names
IL13R; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2
UniProt Entry Name
I13R2_HUMAN

NCBI Summary for IL13RA2

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for IL13RA2

IL13RA2: a type I membrane protein that binds with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). Lacks a cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Often overexpressed in brain tumors. A potential vaccine targets for immunotherapy of glioma. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: extracellular space; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity

Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000