IL17 A/F Active Protein

Name: IL17 A/F Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844486
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844486

Background: Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL17 A/F, Active Protein

Full Product Name

IL17 A / F, Mouse Recombinant

Product Gene Name

IL17 A/F active protein

Product Synonym Names

Interleukin 17 A/F; IL-17A; IL-17F; Interleukin 17A; Interleukin 17F

Sequence

IL-17A subunit: MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
IL -17F subunit: MRKNPKAGVP ALQKAGNCPP LEDNTVRVDI RIFNQNQGIS VPREFQNRSS SPWDYNITRD PHRFPSEIAE AQCRHSGCIN AQGQEDSTMN SVAIQQEILV LRREP

Host

E Coli

Form/Format

Lyophilized without any additives.
Appearance: Lyophilized

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

30.7 kDa.

3D Structure

ModBase 3D Structure for Q62386

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

Endotoxin Level

Measured by kinetic LAL analysis and is typically <= 1 EU/mug protein

Activity (Specifications/test method)

The activity determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts, is typically 75-325 ng/mL.

Biological Activity

The activity determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts, is typically 75-325 ng/mL.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for IL17 A/F active protein

Cytokines; Growth Factors & Hormones; InterleukinsCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; InterleukinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cy

Applications Tested/Suitable for IL17 A/F active protein

SDS-PAGE

Other Notes

Small volumes of IL17 A/F active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17 A/F purchase

MBS844486 is an active protein targeting IL17 A/F. Also known as IL17 A / F, Mouse Recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17 A/F. It may not necessarily be applicable to this product.

NCBI GI #

2498482

NCBI GeneID

16171

NCBI Accession #

Q62386.1

UniProt Primary Accession #

Q62386

UniProt Secondary Accession #

Q60971

UniProt Related Accession #

Q62386

NCBI Official Full Name

Interleukin-17A

NCBI Official Synonym Full Names

interleukin 17A

NCBI Official Symbol

Il17a

NCBI Official Synonym Symbols

Il17; Ctla8; IL-17; Ctla-8; IL-17A

UniProt Protein Name

Interleukin-17A

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

UniProt Gene Name

Il17a

UniProt Synonym Gene Names

Ctla8; Il17; IL-17; IL-17A; CTLA-8

UniProt Entry Name

IL17_MOUSE

NCBI Protein Information

interleukin-17A

UniProt Comments for IL17 A/F

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

Research Articles on IL17 A/F

1. IL-17A can play a key role in the pathogenesis of inflammation-associated arthritis and/or skin disease, as observed in psoriatic arthritis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL17 A/F active protein

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