Endoglin (ENG) Recombinant Protein

ENG: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: nucleoplasm; extracellular space; cell surface; focal adhesion; membrane; cytoplasm; integral to membrane; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; protein homodimerization activity; glycosaminoglycan binding; transforming growth factor beta binding; galactose binding; punt binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: wound healing; heart development; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; extracellular matrix disassembly; smooth muscle development; venous blood vessel morphogenesis; central nervous system vasculogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; negative regulation of protein amino acid autophosphorylation; angiogenesis; heart looping; vasculogenesis; cell adhesion; negative regulation of cell migration; positive regulation of BMP signaling pathway; cell migration; negative regulation of nitric-oxide synthase activity; patterning of blood vessels; positive regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation